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dc.contributor.authorKos, Z
dc.contributor.authorRoblin, E
dc.contributor.authorKim, RS
dc.contributor.authorMichiels, S
dc.contributor.authorGallas, BD
dc.contributor.authorChen, W
dc.contributor.authorvan de Vijver, KK
dc.contributor.authorGoel, S
dc.contributor.authorAdams, S
dc.contributor.authorDemaria, S
dc.contributor.authorViale, G
dc.contributor.authorNielsen, TO
dc.contributor.authorBadve, SS
dc.contributor.authorSymmans, WF
dc.contributor.authorSotiriou, C
dc.contributor.authorRimm, DL
dc.contributor.authorHewitt, S
dc.contributor.authorDenkert, C
dc.contributor.authorLoibl, S
dc.contributor.authorLuen, SJ
dc.contributor.authorBartlett, JMS
dc.contributor.authorSavas, P
dc.contributor.authorPruneri, G
dc.contributor.authorDillon, DA
dc.contributor.authorCheang, MCU
dc.contributor.authorTutt, A
dc.contributor.authorHall, JA
dc.contributor.authorKok, M
dc.contributor.authorHorlings, HM
dc.contributor.authorMadabhushi, A
dc.contributor.authorvan der Laak, J
dc.contributor.authorCiompi, F
dc.contributor.authorLaenkholm, A-V
dc.contributor.authorBellolio, E
dc.contributor.authorGruosso, T
dc.contributor.authorFox, SB
dc.contributor.authorAraya, JC
dc.contributor.authorFloris, G
dc.contributor.authorHudeček, J
dc.contributor.authorVoorwerk, L
dc.contributor.authorBeck, AH
dc.contributor.authorKerner, J
dc.contributor.authorLarsimont, D
dc.contributor.authorDeclercq, S
dc.contributor.authorVan den Eynden, G
dc.contributor.authorPusztai, L
dc.contributor.authorEhinger, A
dc.contributor.authorYang, W
dc.contributor.authorAbdulJabbar, K
dc.contributor.authorYuan, Y
dc.contributor.authorSingh, R
dc.contributor.authorHiley, C
dc.contributor.authorBakir, MA
dc.contributor.authorLazar, AJ
dc.contributor.authorNaber, S
dc.contributor.authorWienert, S
dc.contributor.authorCastillo, M
dc.contributor.authorCurigliano, G
dc.contributor.authorDieci, M-V
dc.contributor.authorAndré, F
dc.contributor.authorSwanton, C
dc.contributor.authorReis-Filho, J
dc.contributor.authorSparano, J
dc.contributor.authorBalslev, E
dc.contributor.authorChen, I-C
dc.contributor.authorStovgaard, EIS
dc.contributor.authorPogue-Geile, K
dc.contributor.authorBlenman, KRM
dc.contributor.authorPenault-Llorca, F
dc.contributor.authorSchnitt, S
dc.contributor.authorLakhani, SR
dc.contributor.authorVincent-Salomon, A
dc.contributor.authorRojo, F
dc.contributor.authorBraybrooke, JP
dc.contributor.authorHanna, MG
dc.contributor.authorSoler-Monsó, MT
dc.contributor.authorBethmann, D
dc.contributor.authorCastaneda, CA
dc.contributor.authorWillard-Gallo, K
dc.contributor.authorSharma, A
dc.contributor.authorLien, H-C
dc.contributor.authorFineberg, S
dc.contributor.authorThagaard, J
dc.contributor.authorComerma, L
dc.contributor.authorGonzalez-Ericsson, P
dc.contributor.authorBrogi, E
dc.contributor.authorLoi, S
dc.contributor.authorSaltz, J
dc.contributor.authorKlaushen, F
dc.contributor.authorCooper, L
dc.contributor.authorAmgad, M
dc.contributor.authorMoore, DA
dc.contributor.authorSalgado, R
dc.contributor.authorInternational Immuno-Oncology Biomarker Working Group
dc.date.accessioned2020-04-14T11:40:28Z
dc.date.issued2020-01
dc.identifier.citationNPJ breast cancer, 2020, 6 pp. 17 - ?
dc.identifier.issn2374-4677
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/3590
dc.identifier.eissn2374-4677
dc.identifier.doi10.1038/s41523-020-0156-0
dc.description.abstractStromal tumor-infiltrating lymphocytes (sTILs) are important prognostic and predictive biomarkers in triple-negative (TNBC) and HER2-positive breast cancer. Incorporating sTILs into clinical practice necessitates reproducible assessment. Previously developed standardized scoring guidelines have been widely embraced by the clinical and research communities. We evaluated sources of variability in sTIL assessment by pathologists in three previous sTIL ring studies. We identify common challenges and evaluate impact of discrepancies on outcome estimates in early TNBC using a newly-developed prognostic tool. Discordant sTIL assessment is driven by heterogeneity in lymphocyte distribution. Additional factors include: technical slide-related issues; scoring outside the tumor boundary; tumors with minimal assessable stroma; including lymphocytes associated with other structures; and including other inflammatory cells. Small variations in sTIL assessment modestly alter risk estimation in early TNBC but have the potential to affect treatment selection if cutpoints are employed. Scoring and averaging multiple areas, as well as use of reference images, improve consistency of sTIL evaluation. Moreover, to assist in avoiding the pitfalls identified in this analysis, we developed an educational resource available at www.tilsinbreastcancer.org/pitfalls.
dc.formatElectronic-eCollection
dc.format.extent17 - ?
dc.languageeng
dc.language.isoeng
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.subjectInternational Immuno-Oncology Biomarker Working Group
dc.titlePitfalls in assessing stromal tumor infiltrating lymphocytes (sTILs) in breast cancer.
dc.typeJournal Article
dcterms.dateAccepted2020-03-02
rioxxterms.versionofrecord10.1038/s41523-020-0156-0
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0
rioxxterms.licenseref.startdate2020-01
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfNPJ breast cancer
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies/Genomic Analysis – Clinical Trials
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies/Genomic Analysis – Clinical Trials
pubs.publication-statusPublished
pubs.volume6
pubs.embargo.termsNot known
icr.researchteamGenomic Analysis – Clinical Trialsen_US
dc.contributor.icrauthorCheang, Chonen
dc.contributor.icrauthorTutt, Andrewen


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