dc.contributor.author | Ho, JSY | |
dc.contributor.author | Angel, M | |
dc.contributor.author | Ma, Y | |
dc.contributor.author | Sloan, E | |
dc.contributor.author | Wang, G | |
dc.contributor.author | Martinez-Romero, C | |
dc.contributor.author | Alenquer, M | |
dc.contributor.author | Roudko, V | |
dc.contributor.author | Chung, L | |
dc.contributor.author | Zheng, S | |
dc.contributor.author | Chang, M | |
dc.contributor.author | Fstkchyan, Y | |
dc.contributor.author | Clohisey, S | |
dc.contributor.author | Dinan, AM | |
dc.contributor.author | Gibbs, J | |
dc.contributor.author | Gifford, R | |
dc.contributor.author | Shen, R | |
dc.contributor.author | Gu, Q | |
dc.contributor.author | Irigoyen, N | |
dc.contributor.author | Campisi, L | |
dc.contributor.author | Huang, C | |
dc.contributor.author | Zhao, N | |
dc.contributor.author | Jones, JD | |
dc.contributor.author | van Knippenberg, I | |
dc.contributor.author | Zhu, Z | |
dc.contributor.author | Moshkina, N | |
dc.contributor.author | Meyer, L | |
dc.contributor.author | Noel, J | |
dc.contributor.author | Peralta, Z | |
dc.contributor.author | Rezelj, V | |
dc.contributor.author | Kaake, R | |
dc.contributor.author | Rosenberg, B | |
dc.contributor.author | Wang, B | |
dc.contributor.author | Wei, J | |
dc.contributor.author | Paessler, S | |
dc.contributor.author | Wise, HM | |
dc.contributor.author | Johnson, J | |
dc.contributor.author | Vannini, A | |
dc.contributor.author | Amorim, MJ | |
dc.contributor.author | Baillie, JK | |
dc.contributor.author | Miraldi, ER | |
dc.contributor.author | Benner, C | |
dc.contributor.author | Brierley, I | |
dc.contributor.author | Digard, P | |
dc.contributor.author | Łuksza, M | |
dc.contributor.author | Firth, AE | |
dc.contributor.author | Krogan, N | |
dc.contributor.author | Greenbaum, BD | |
dc.contributor.author | MacLeod, MK | |
dc.contributor.author | van Bakel, H | |
dc.contributor.author | Garcìa-Sastre, A | |
dc.contributor.author | Yewdell, JW | |
dc.contributor.author | Hutchinson, E | |
dc.contributor.author | Marazzi, I | |
dc.date.accessioned | 2020-07-06T13:17:21Z | |
dc.date.issued | 2020-06-25 | |
dc.identifier.citation | Cell, 2020, 181 (7), pp. 1502 - 1517.e23 | |
dc.identifier.issn | 0092-8674 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/3810 | |
dc.identifier.eissn | 1097-4172 | |
dc.identifier.doi | 10.1016/j.cell.2020.05.035 | |
dc.description.abstract | RNA viruses are a major human health threat. The life cycles of many highly pathogenic RNA viruses like influenza A virus (IAV) and Lassa virus depends on host mRNA, because viral polymerases cleave 5'-m7G-capped host transcripts to prime viral mRNA synthesis ("cap-snatching"). We hypothesized that start codons within cap-snatched host transcripts could generate chimeric human-viral mRNAs with coding potential. We report the existence of this mechanism of gene origination, which we named "start-snatching." Depending on the reading frame, start-snatching allows the translation of host and viral "untranslated regions" (UTRs) to create N-terminally extended viral proteins or entirely novel polypeptides by genetic overprinting. We show that both types of chimeric proteins are made in IAV-infected cells, generate T cell responses, and contribute to virulence. Our results indicate that during infection with IAV, and likely a multitude of other human, animal and plant viruses, a host-dependent mechanism allows the genesis of hybrid genes. | |
dc.format | Print-Electronic | |
dc.format.extent | 1502 - 1517.e23 | |
dc.language | eng | |
dc.language.iso | eng | |
dc.publisher | CELL PRESS | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0 | |
dc.title | Hybrid Gene Origination Creates Human-Virus Chimeric Proteins during Infection. | |
dc.type | Journal Article | |
dcterms.dateAccepted | 2020-05-18 | |
rioxxterms.versionofrecord | 10.1016/j.cell.2020.05.035 | |
rioxxterms.licenseref.uri | https://creativecommons.org/licenses/by/4.0 | |
rioxxterms.licenseref.startdate | 2020-06-18 | |
rioxxterms.type | Journal Article/Review | |
dc.relation.isPartOf | Cell | |
pubs.issue | 7 | |
pubs.notes | Not known | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Structural Biology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Structural Biology/Vannini Group | |
pubs.publication-status | Published | |
pubs.volume | 181 | |
pubs.embargo.terms | Not known | |
icr.researchteam | Vannini Group | |
dc.contributor.icrauthor | Shen, Rong | |
dc.contributor.icrauthor | Vannini, Alessandro | |