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dc.contributor.authorBlazeby, JM
dc.contributor.authorHall, E
dc.contributor.authorAaronson, NK
dc.contributor.authorLloyd, L
dc.contributor.authorWaters, R
dc.contributor.authorKelly, JD
dc.contributor.authorFayers, P
dc.date.accessioned2020-08-06T14:52:45Z
dc.date.issued2014-12
dc.identifier.citationEuropean urology, 2014, 66 (6), pp. 1148 - 1156
dc.identifier.issn0302-2838
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/3918
dc.identifier.eissn1873-7560
dc.identifier.doi10.1016/j.eururo.2014.02.034
dc.description.abstractBackground Well-developed and well-tested patient-reported outcome measures for non-muscle-invasive bladder cancer (NMIBC) are required.Objective To test and adapt the scale structure and explore the psychometric properties of the European Organisation for Research and Treatment of Cancer (EORTC) questionnaire for NMIBC.Design, setting, and participants A total of 433 patients in the Bladder COX-2 Inhibition Trial (BOXIT) completed the EORTC QLQ-C30 and NMIBC questionnaires. BOXIT is evaluating the addition of celecoxib to standard treatment in high- and intermediate-risk NMIBC.Outcome measurements and statistical analysis Multitrait scaling investigated and adapted the questionnaire scale structure and evaluated the reliability and validity of the revised scales, as well as responsiveness to change.Results and limitations A total of 410 patients (94.7%) (79.3% men, 74.6% high risk) returned baseline forms, and the questionnaire response rate was 88.2%. Multitrait scaling confirmed six scales and five single items. Scales and items demonstrated significant differences between patients with good and poor performance status scores (p<0.001). Men reported better sexual function than women (p<0.001). Scale and single-item module scores were not highly correlated with QLQ-C30 scores (evidence of discriminant validity), and the module was responsive to changes in health over time. International and test-retest data are required.Conclusions This study demonstrates the evidence-driven adapted scale structure and psychometric data of the EORTC QLQ-NMIBC24 module to use in clinical trials of patients with high- or intermediate-risk bladder cancer.
dc.formatPrint-Electronic
dc.format.extent1148 - 1156
dc.languageeng
dc.language.isoeng
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.subjectHumans
dc.subjectNeoplasm Invasiveness
dc.subjectFever
dc.subjectCombined Modality Therapy
dc.subjectReproducibility of Results
dc.subjectSexuality
dc.subjectAnxiety
dc.subjectPsychometrics
dc.subjectSex Factors
dc.subjectHealth Status
dc.subjectQuality of Life
dc.subjectAdult
dc.subjectAged
dc.subjectAged, 80 and over
dc.subjectMiddle Aged
dc.subjectFemale
dc.subjectMale
dc.subjectCyclooxygenase 2 Inhibitors
dc.subjectUrinary Bladder Neoplasms
dc.subjectSocial Participation
dc.subjectLower Urinary Tract Symptoms
dc.subjectPatient Outcome Assessment
dc.subjectSurveys and Questionnaires
dc.subjectCelecoxib
dc.titleValidation and reliability testing of the EORTC QLQ-NMIBC24 questionnaire module to assess patient-reported outcomes in non-muscle-invasive bladder cancer.
dc.typeJournal Article
dcterms.dateAccepted2014-02-13
rioxxterms.versionofrecord10.1016/j.eururo.2014.02.034
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0
rioxxterms.licenseref.startdate2014-12
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfEuropean urology
pubs.issue6
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies/ICR-CTSU Urology and Head and Neck Trials Team
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies/ICR-CTSU Urology and Head and Neck Trials Team
pubs.publication-statusPublished
pubs.volume66
pubs.embargo.termsNot known
icr.researchteamICR-CTSU Urology and Head and Neck Trials Teamen_US
dc.contributor.icrauthorHall, Emmaen


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