Browsing Cancer Therapeutics by author "Grabovska, Yura"
Now showing items 1-2 of 2
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DIPG Harbors Alterations Targetable by MEK Inhibitors, with Acquired Resistance Mechanisms Overcome by Combinatorial Inhibition.
Izquierdo, E; Carvalho, DM; Mackay, A; Temelso, S; Boult, JKR; et al. (AMER ASSOC CANCER RESEARCH, 2022-03-01)UNLABELLED: The survival of children with diffuse intrinsic pontine glioma (DIPG) remains dismal, with new treatments desperately needed. In a prospective biopsy-stratified clinical trial, we combined detailed molecular ... -
Inter and intra-tumor heterogeneity of paediatric type diffuse high-grade gliomas revealed by single-cell mass cytometry.
Petrilli, LL; Fuoco, C; Palma, A; Pasquini, L; Pericoli, G; et al. (FRONTIERS MEDIA SA, 2022-12-08)Paediatric-type diffuse high-grade gliomas (PDHGG) are aggressive tumors affecting children and young adults, with no effective treatment. These highly heterogeneous malignancies arise in different sites of the Central ...