Now showing items 1-20 of 26

    • Characterization of the transcriptional and metabolic responses of pediatric high grade gliomas to mTOR-HIF-1α axis inhibition. 

      Nguyen, A; Moussallieh, FM; Mackay, A; Cicek, AE; Coca, A; Chenard, MP; Weingertner, N; Lhermitte, B; Letouzé, E; Guérin, E; Pencreach, E; Jannier, S; Guenot, D; Namer, IJ; Jones, C; Entz-Werlé, N (2017-09-22)
      Pediatric high grade glioma (pHGGs), including sus-tentorial and diffuse intrinsic pontine gliomas, are known to have a very dismal prognosis. For instance, even an increased knowledge on molecular biology driving this ...
    • Characterizing and targeting PDGFRA alterations in pediatric high-grade glioma. 

      Koschmann, C; Zamler, D; MacKay, A; Robinson, D; Wu, YM; Doherty, R; Marini, B; Tran, D; Garton, H; Muraszko, K; Robertson, P; Leonard, M; Zhao, L; Bixby, D; Peterson, L; Camelo-Piragua, S; Jones, C; Mody, R; Lowenstein, PR; Castro, MG (2016-08-25)
      Pediatric high-grade glioma (HGG, WHO Grade III and IV) is a devastating brain tumor with a median survival of less than two years. PDGFRA is frequently mutated/ amplified in pediatric HGG, but the significance of this ...
    • Clinical, Radiologic, Pathologic, and Molecular Characteristics of Long-Term Survivors of Diffuse Intrinsic Pontine Glioma (DIPG): A Collaborative Report From the International and European Society for Pediatric Oncology DIPG Registries. 

      Hoffman, LM; Veldhuijzen van Zanten, SEM; Colditz, N; Baugh, J; Chaney, B; Hoffmann, M; Lane, A; Fuller, C; Miles, L; Hawkins, C; Bartels, U; Bouffet, E; Goldman, S; Leary, S; Foreman, NK; Packer, R; Warren, KE; Broniscer, A; Kieran, MW; Minturn, J; Comito, M; Broxson, E; Shih, C-S; Khatua, S; Chintagumpala, M; Carret, AS; Escorza, NY; Hassall, T; Ziegler, DS; Gottardo, N; Dholaria, H; Doughman, R; Benesch, M; Drissi, R; Nazarian, J; Jabado, N; Boddaert, N; Varlet, P; Giraud, G; Castel, D; Puget, S; Jones, C; Hulleman, E; Modena, P; Giagnacovo, M; Antonelli, M; Pietsch, T; Gielen, GH; Jones, DTW; Sturm, D; Pfister, SM; Gerber, NU; Grotzer, MA; Pfaff, E; von Bueren, AO; Hargrave, D; Solanki, GA; Jadrijevic Cvrlje, F; Kaspers, GJL; Vandertop, WP; Grill, J; Bailey, S; Biassoni, V; Massimino, M; Calmon, R; Sanchez, E; Bison, B; Warmuth-Metz, M; Leach, J; Jones, B; van Vuurden, DG; Kramm, CM; Fouladi, M (2018-07-01)
      Purpose Diffuse intrinsic pontine glioma (DIPG) is a brainstem malignancy with a median survival of < 1 year. The International and European Society for Pediatric Oncology DIPG Registries collaborated to compare clinical, ...
    • Copy Number Profiling of Brazilian Astrocytomas. 

      Bidinotto, LT; Torrieri, R; Mackay, A; Almeida, GC; Viana-Pereira, M; Cruvinel-Carloni, A; Spina, ML; Campanella, NC; Pereira de Menezes, W; Clara, CA; Becker, AP; Jones, C; Reis, RM (2016-01)
      Copy number alterations (CNA) are one of the driving mechanisms of glioma tumorigenesis, and are currently used as important biomarkers in the routine setting. Therefore, we performed CNA profiling of 65 astrocytomas of ...
    • Development of a targeted sequencing approach to identify prognostic, predictive and diagnostic markers in paediatric solid tumours. 

      Izquierdo, E; Yuan, L; George, S; Hubank, M; Jones, C; Proszek, P; Shipley, J; Gatz, SA; Stinson, C; Moore, AS; Clifford, SC; Hicks, D; Lindsey, JC; Hill, RM; Jacques, TS; Chalker, J; Thway, K; O'Connor, S; Marshall, L; Moreno, L; Pearson, A; Chesler, L; Walker, BA; De Castro, DG (2017-12-19)
      The implementation of personalised medicine in childhood cancers has been limited by a lack of clinically validated multi-target sequencing approaches specific for paediatric solid tumours. In order to support innovative ...
    • Development of the SIOPE DIPG network, registry and imaging repository: a collaborative effort to optimize research into a rare and lethal disease. 

      Veldhuijzen van Zanten, SEM; Baugh, J; Chaney, B; De Jongh, D; Sanchez Aliaga, E; Barkhof, F; Noltes, J; De Wolf, R; Van Dijk, J; Cannarozzo, A; Damen-Korbijn, CM; Lieverst, JA; Colditz, N; Hoffmann, M; Warmuth-Metz, M; Bison, B; Jones, DTW; Sturm, D; Gielen, GH; Jones, C; Hulleman, E; Calmon, R; Castel, D; Varlet, P; Giraud, G; Slavc, I; Van Gool, S; Jacobs, S; Jadrijevic-Cvrlje, F; Sumerauer, D; Nysom, K; Pentikainen, V; Kivivuori, S-M; Leblond, P; Entz-Werle, N; von Bueren, AO; Kattamis, A; Hargrave, DR; Hauser, P; Garami, M; Thorarinsdottir, HK; Pears, J; Gandola, L; Rutkauskiene, G; Janssens, GO; Torsvik, IK; Perek-Polnik, M; Gil-da-Costa, MJ; Zheludkova, O; Shats, L; Deak, L; Kitanovski, L; Cruz, O; Morales La Madrid, A; Holm, S; Gerber, N; Kebudi, R; Grundy, R; Lopez-Aguilar, E; Zapata-Tarres, M; Emmerik, J; Hayden, T; Bailey, S; Biassoni, V; Massimino, M; Grill, J; Vandertop, WP; Kaspers, GJL; Fouladi, M; Kramm, CM; van Vuurden, DG; members of the SIOPE DIPG Network (2017-04)
      Diffuse intrinsic pontine glioma (DIPG) is a rare and deadly childhood malignancy. After 40 years of mostly single-center, often non-randomized trials with variable patient inclusions, there has been no improvement in ...
    • DNA methylation-based classification of central nervous system tumours. 

      Capper, D; Jones, DTW; Sill, M; Hovestadt, V; Schrimpf, D; Sturm, D; Koelsche, C; Sahm, F; Chavez, L; Reuss, DE; Kratz, A; Wefers, AK; Huang, K; Pajtler, KW; Schweizer, L; Stichel, D; Olar, A; Engel, NW; Lindenberg, K; Harter, PN; Braczynski, AK; Plate, KH; Dohmen, H; Garvalov, BK; Coras, R; Hölsken, A; Hewer, E; Bewerunge-Hudler, M; Schick, M; Fischer, R; Beschorner, R; Schittenhelm, J; Staszewski, O; Wani, K; Varlet, P; Pages, M; Temming, P; Lohmann, D; Selt, F; Witt, H; Milde, T; Witt, O; Aronica, E; Giangaspero, F; Rushing, E; Scheurlen, W; Geisenberger, C; Rodriguez, FJ; Becker, A; Preusser, M; Haberler, C; Bjerkvig, R; Cryan, J; Farrell, M; Deckert, M; Hench, J; Frank, S; Serrano, J; Kannan, K; Tsirigos, A; Brück, W; Hofer, S; Brehmer, S; Seiz-Rosenhagen, M; Hänggi, D; Hans, V; Rozsnoki, S; Hansford, JR; Kohlhof, P; Kristensen, BW; Lechner, M; Lopes, B; Mawrin, C; Ketter, R; Kulozik, A; Khatib, Z; Heppner, F; Koch, A; Jouvet, A; Keohane, C; Mühleisen, H; Mueller, W; Pohl, U; Prinz, M; Benner, A; Zapatka, M; Gottardo, NG; Driever, PH; Kramm, CM; Müller, HL; Rutkowski, S; von Hoff, K; Frühwald, MC; Gnekow, A; Fleischhack, G; Tippelt, S; Calaminus, G; Monoranu, C-M; Perry, A; Jones, C; Jacques, TS; Radlwimmer, B; Gessi, M; Pietsch, T; Schramm, J; Schackert, G; Westphal, M; Reifenberger, G; Wesseling, P; Weller, M; Collins, VP; Blümcke, I; Bendszus, M; Debus, J; Huang, A; Jabado, N; Northcott, PA; Paulus, W; Gajjar, A; Robinson, GW; Taylor, MD; Jaunmuktane, Z; Ryzhova, M; Platten, M; Unterberg, A; Wick, W; Karajannis, MA; Mittelbronn, M; Acker, T; Hartmann, C; Aldape, K; Schüller, U; Buslei, R; Lichter, P; Kool, M; Herold-Mende, C; Ellison, DW; Hasselblatt, M; Snuderl, M; Brandner, S; Korshunov, A; von Deimling, A; Pfister, SM (2018-03-22)
      Accurate pathological diagnosis is crucial for optimal management of patients with cancer. For the approximately 100 known tumour types of the central nervous system, standardization of the diagnostic process has been shown ...
    • Evaluation of the Response of Intracranial Xenografts to VEGF Signaling Inhibition Using Multiparametric MRI. 

      Boult, JKR; Box, G; Vinci, M; Perryman, L; Eccles, SA; Jones, C; Robinson, SP (2017-09)
      Vascular endothelial growth factor A (VEGF-A) is considered one of the most important factors in tumor angiogenesis, and consequently, a number of therapeutics have been developed to inhibit VEGF signaling. Therapeutic ...
    • Immuno-PET in Pontine Glioma: More Than Meets the Eye? 

      Oyen, WJG; Jones, C (2018-04)
    • In vitro nuclear magnetic resonance spectroscopy metabolic biomarkers for the combination of temozolomide with PI3K inhibition in paediatric glioblastoma cells. 

      Al-Saffar, NMS; Agliano, A; Marshall, LV; Jackson, LE; Balarajah, G; Sidhu, J; Clarke, PA; Jones, C; Workman, P; Pearson, ADJ; Leach, MO (2017)
      Recent experimental data showed that the PI3K pathway contributes to resistance to temozolomide (TMZ) in paediatric glioblastoma and that this effect is reversed by combination treatment of TMZ with a PI3K inhibitor. Our ...
    • Integrated Molecular Meta-Analysis of 1,000 Pediatric High-Grade and Diffuse Intrinsic Pontine Glioma. 

      Mackay, A; Burford, A; Carvalho, D; Izquierdo, E; Fazal-Salom, J; Taylor, KR; Bjerke, L; Clarke, M; Vinci, M; Nandhabalan, M; Temelso, S; Popov, S; Molinari, V; Raman, P; Waanders, AJ; Han, HJ; Gupta, S; Marshall, L; Zacharoulis, S; Vaidya, S; Mandeville, HC; Bridges, LR; Martin, AJ; Al-Sarraj, S; Chandler, C; Ng, H-K; Li, X; Mu, K; Trabelsi, S; Brahim, DH-B; Kisljakov, AN; Konovalov, DM; Moore, AS; Carcaboso, AM; Sunol, M; de Torres, C; Cruz, O; Mora, J; Shats, LI; Stavale, JN; Bidinotto, LT; Reis, RM; Entz-Werle, N; Farrell, M; Cryan, J; Crimmins, D; Caird, J; Pears, J; Monje, M; Debily, M-A; Castel, D; Grill, J; Hawkins, C; Nikbakht, H; Jabado, N; Baker, SJ; Pfister, SM; Jones, DTW; Fouladi, M; von Bueren, AO; Baudis, M; Resnick, A; Jones, C (2017-10-09)
      We collated data from 157 unpublished cases of pediatric high-grade glioma and diffuse intrinsic pontine glioma and 20 publicly available datasets in an integrated analysis of >1,000 cases. We identified co-segregating ...
    • Integrated Molecular Meta-Analysis of 1,000 Pediatric High-Grade and Diffuse Intrinsic Pontine Glioma. 

      Mackay, A; Burford, A; Carvalho, D; Izquierdo, E; Fazal-Salom, J; Taylor, KR; Bjerke, L; Clarke, M; Vinci, M; Nandhabalan, M; Temelso, S; Popov, S; Molinari, V; Raman, P; Waanders, AJ; Han, HJ; Gupta, S; Marshall, L; Zacharoulis, S; Vaidya, S; Mandeville, HC; Bridges, LR; Martin, AJ; Al-Sarraj, S; Chandler, C; Ng, H-K; Li, X; Mu, K; Trabelsi, S; Brahim, DH-B; Kisljakov, AN; Konovalov, DM; Moore, AS; Carcaboso, AM; Sunol, M; de Torres, C; Cruz, O; Mora, J; Shats, LI; Stavale, JN; Bidinotto, LT; Reis, RM; Entz-Werle, N; Farrell, M; Cryan, J; Crimmins, D; Caird, J; Pears, J; Monje, M; Debily, M-A; Castel, D; Grill, J; Hawkins, C; Nikbakht, H; Jabado, N; Baker, SJ; Pfister, SM; Jones, DTW; Fouladi, M; von Bueren, AO; Baudis, M; Resnick, A; Jones, C (2017-10-09)
      We collated data from 157 unpublished cases of pediatric high-grade glioma and diffuse intrinsic pontine glioma and 20 publicly available datasets in an integrated analysis of >1,000 cases. We identified co-segregating ...
    • Integrated Molecular Meta-Analysis of 1,000 Pediatric High-Grade and Diffuse Intrinsic Pontine Glioma. 

      Mackay, A; Burford, A; Carvalho, D; Izquierdo, E; Fazal-Salom, J; Taylor, KR; Bjerke, L; Clarke, M; Vinci, M; Nandhabalan, M; Temelso, S; Popov, S; Molinari, V; Raman, P; Waanders, AJ; Han, HJ; Gupta, S; Marshall, L; Zacharoulis, S; Vaidya, S; Mandeville, HC; Bridges, LR; Martin, AJ; Al-Sarraj, S; Chandler, C; Ng, H-K; Li, X; Mu, K; Trabelsi, S; Brahim, DH-B; Kisljakov, AN; Konovalov, DM; Moore, AS; Carcaboso, AM; Sunol, M; de Torres, C; Cruz, O; Mora, J; Shats, LI; Stavale, JN; Bidinotto, LT; Reis, RM; Entz-Werle, N; Farrell, M; Cryan, J; Crimmins, D; Caird, J; Pears, J; Monje, M; Debily, M-A; Castel, D; Grill, J; Hawkins, C; Nikbakht, H; Jabado, N; Baker, SJ; Pfister, SM; Jones, DTW; Fouladi, M; von Bueren, AO; Baudis, M; Resnick, A; Jones, C (2017-10-09)
      We collated data from 157 unpublished cases of pediatric high-grade glioma and diffuse intrinsic pontine glioma and 20 publicly available datasets in an integrated analysis of >1,000 cases. We identified co-segregating ...
    • Investigating intracranial tumour growth patterns with multiparametric MRI incorporating Gd-DTPA and USPIO-enhanced imaging. 

      Boult, JK; Borri, M; Jury, A; Popov, S; Box, G; Perryman, L; Eccles, SA; Jones, C; Robinson, SP (2016-09-27)
      High grade and metastatic brain tumours exhibit considerable spatial variations in proliferation, angiogenesis, invasion, necrosis and oedema. Vascular heterogeneity arising from vascular co-option in regions of invasive ...
    • Molecular, Pathological, Radiological, and Immune Profiling of Non-brainstem Pediatric High-Grade Glioma from the HERBY Phase II Randomized Trial. 

      Mackay, A; Burford, A; Molinari, V; Jones, DTW; Izquierdo, E; Brouwer-Visser, J; Giangaspero, F; Haberler, C; Pietsch, T; Jacques, TS; Figarella-Branger, D; Rodriguez, D; Morgan, PS; Raman, P; Waanders, AJ; Resnick, AC; Massimino, M; Garrè, ML; Smith, H; Capper, D; Pfister, SM; Würdinger, T; Tam, R; Garcia, J; Thakur, MD; Vassal, G; Grill, J; Jaspan, T; Varlet, P; Jones, C (2018-05-14)
      The HERBY trial was a phase II open-label, randomized, multicenter trial evaluating bevacizumab (BEV) in addition to temozolomide/radiotherapy in patients with newly diagnosed non-brainstem high-grade glioma (HGG) between ...
    • Multifaceted dysregulation of the epidermal growth factor receptor pathway in clear cell sarcoma of the kidney. 

      Little, SE; Bax, DA; Rodriguez-Pinilla, M; Natrajan, R; Messahel, B; Pritchard-Jones, K; Vujanic, GM; Reis-Filho, JS; Jones, C (2007-08)
      PURPOSE: Epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase overexpressed in a variety of human malignancies, against which targeted therapies have shown efficacy in lung and brain tumors. Clinical ...
    • Neural Precursor-Derived Pleiotrophin Mediates Subventricular Zone Invasion by Glioma. 

      Qin, EY; Cooper, DD; Abbott, KL; Lennon, J; Nagaraja, S; Mackay, A; Jones, C; Vogel, H; Jackson, PK; Monje, M (2017-08-24)
      The lateral ventricle subventricular zone (SVZ) is a frequent and consequential site of pediatric and adult glioma spread, but the cellular and molecular mechanisms mediating this are poorly understood. We demonstrate that ...