Browsing Cancer Therapeutics by author "Chopra, Rajesh"
Now showing items 1-2 of 2
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A critical evaluation of the approaches to targeted protein degradation for drug discovery.
Chopra, R; Sadok, A; Collins, I (Elsevier BV, 2019-04-03)There is a great deal of excitement around the concept of targeting proteins for degradation as an alternative to conventional inhibitory small molecules and antibodies. Protein degradation can be undertaken by bifunctional ... -
Chemical approaches to targeted protein degradation through modulation of the ubiquitin-proteasome pathway.
Collins, I; Wang, H; Caldwell, JJ; Chopra, R (PORTLAND PRESS LTD, 2017-03-15)Manipulation of the ubiquitin-proteasome system to achieve targeted degradation of proteins within cells using chemical tools and drugs has the potential to transform pharmacological and therapeutic approaches in cancer ...