Browsing Cancer Therapeutics by author "Cornish, Alexander"
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Analysis of 10,478 cancer genomes identifies candidate driver genes and opportunities for precision oncology.
Kinnersley, B; Sud, A; Everall, A; Cornish, AJ; Chubb, D; et al. (NATURE PORTFOLIO, 2024-06-18)Tumor genomic profiling is increasingly seen as a prerequisite to guide the treatment of patients with cancer. To explore the value of whole-genome sequencing (WGS) in broadening the scope of cancers potentially amenable ... -
Genomic landscape of platinum resistant and sensitive testicular cancers.
Loveday, C; Litchfield, K; Proszek, PZ; Cornish, AJ; Santo, F; et al. (NATURE PUBLISHING GROUP, 2020-05-04)While most testicular germ cell tumours (TGCTs) exhibit exquisite sensitivity to platinum chemotherapy, ~10% are platinum resistant. To gain insight into the underlying mechanisms, we undertake whole exome sequencing and ...