Browsing Cancer Therapeutics by author "Pearl, Laurence"
Now showing items 1-3 of 3
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MoKCa database--mutations of kinases in cancer.
Richardson, CJ; Gao, Q; Mitsopoulous, C; Zvelebil, M; Pearl, LH; et al. (OXFORD UNIV PRESS, 2009-01-01)Members of the protein kinase family are amongst the most commonly mutated genes in human cancer, and both mutated and activated protein kinases have proved to be tractable targets for the development of new anticancer ... -
Restricting direct interaction of CDC37 with HSP90 does not compromise chaperoning of client proteins.
Smith, JR; de Billy, E; Hobbs, S; Powers, M; Prodromou, C; et al. (NATURE PUBLISHING GROUP, 2015-01-02)The HSP90 molecular chaperone plays a key role in the maturation, stability and activation of its clients, including many oncogenic proteins. Kinases are a substantial and important subset of clients requiring the key ... -
Solution structure of the Hop TPR2A domain and investigation of target druggability by NMR, biochemical and in silico approaches.
Darby, JF; Vidler, LR; Simpson, PJ; Al-Lazikani, B; Matthews, SJ; et al. (NATURE RESEARCH, 2020-09-29)Heat shock protein 90 (Hsp90) is a molecular chaperone that plays an important role in tumour biology by promoting the stabilisation and activity of oncogenic 'client' proteins. Inhibition of Hsp90 by small-molecule drugs, ...