Browsing Cancer Therapeutics by author "Caravagna, Giulio"
Now showing items 1-2 of 2
-
Detecting repeated cancer evolution from multi-region tumor sequencing data.
Caravagna, G; Giarratano, Y; Ramazzotti, D; Tomlinson, I; Graham, TA; et al. (NATURE PUBLISHING GROUP, 2018-08-31)Recurrent successions of genomic changes, both within and between patients, reflect repeated evolutionary processes that are valuable for the anticipation of cancer progression. Multi-region sequencing allows the temporal ... -
Spatially constrained tumour growth affects the patterns of clonal selection and neutral drift in cancer genomic data.
Chkhaidze, K; Heide, T; Werner, B; Williams, MJ; Huang, W; et al. (PUBLIC LIBRARY SCIENCE, 2019-07-29)Quantification of the effect of spatial tumour sampling on the patterns of mutations detected in next-generation sequencing data is largely lacking. Here we use a spatial stochastic cellular automaton model of tumour growth ...