Browsing Cancer Therapeutics by author "Richards, Gareth"
Discovery of a Chemical Probe Bisamide (CCT251236): An Orally Bioavailable Efficacious Pirin Ligand from a Heat Shock Transcription Factor 1 (HSF1) Phenotypic Screen. Cheeseman, MD; Chessum, NEA; Rye, CS; Pasqua, AE; Tucker, MJ; Wilding, B; Evans, LE; Lepri, S; Richards, M; Sharp, SY; Ali, S; Rowlands, M; O'Fee, L; Miah, A; Hayes, A; Henley, AT; Powers, M; Te Poele, R; De Billy, E; Pellegrino, L; Raynaud, F; Burke, R; van Montfort, RLM; Eccles, SA; Workman, P; Jones, K (2017-01-12)Phenotypic screens, which focus on measuring and quantifying discrete cellular changes rather than affinity for individual recombinant proteins, have recently attracted renewed interest as an efficient strategy for drug ...
Impact of genetic modulation of SULT1A enzymes on DNA adduct formation by aristolochic acids and 3‑nitrobenzanthrone Mirza, A; Arlt, VM; Meinl, W; Florian, S; Nagy, E; Barta, F; Thomann, M; Mrizova, I; Krais, AM; Liu, M; Richards, M; Kopka, K; Phillips, DH; Glatt, H; Stiborova, M; Schmeiser, HH
Welford, AJ; Caldwell, JJ; Liu, M; Richards, M; Brown, N; Lomas, C; Tizzard, GJ; Pitak, MB; Coles, SJ; Eccles, SA; Raynaud, FI; Collins, I (2016-04)The 2,11-cembranoid family of natural products has been used as inspiration for the synthesis of a structurally simplified, functionally diverse library of octahydroisobenzofuran-based compounds designed to augment a typical ...