Browsing Cancer Therapeutics by author "Heuss, Sara Farrah"
Now showing items 1-2 of 2
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A PI3K- and GTPase-independent Rac1-mTOR mechanism mediates MET-driven anchorage-independent cell growth but not migration.
Hervieu, A; Heuss, SF; Zhang, C; Barrow-McGee, R; Joffre, C; et al. (AMER ASSOC ADVANCEMENT SCIENCE, 2020-06-23)Receptor tyrosine kinases (RTKs) are often overexpressed or mutated in cancers and drive tumor growth and metastasis. In the current model of RTK signaling, including that of MET, downstream phosphatidylinositol 3-kinase ... -
A systematic molecular and pharmacologic evaluation of AKT inhibitors reveals new insight into their biological activity.
Kostaras, E; Kaserer, T; Lazaro, G; Heuss, SF; Hussain, A; et al. (SPRINGERNATURE, 2020-08-18)BACKGROUND: AKT, a critical effector of the phosphoinositide 3-kinase (PI3K) signalling cascade, is an intensely pursued therapeutic target in oncology. Two distinct classes of AKT inhibitors have been in clinical development, ...