dc.contributor.author | Barrow-McGee, R | |
dc.contributor.author | Kishi, N | |
dc.contributor.author | Joffre, C | |
dc.contributor.author | Ménard, L | |
dc.contributor.author | Hervieu, A | |
dc.contributor.author | Bakhouche, BA | |
dc.contributor.author | Noval, AJ | |
dc.contributor.author | Mai, A | |
dc.contributor.author | Guzmán, C | |
dc.contributor.author | Robbez-Masson, L | |
dc.contributor.author | Iturrioz, X | |
dc.contributor.author | Hulit, J | |
dc.contributor.author | Brennan, CH | |
dc.contributor.author | Hart, IR | |
dc.contributor.author | Parker, PJ | |
dc.contributor.author | Ivaska, J | |
dc.contributor.author | Kermorgant, S | |
dc.date.accessioned | 2020-08-27T10:21:44Z | |
dc.date.issued | 2016-06-23 | |
dc.identifier.citation | Nature communications, 2016, 7 pp. 11942 - ? | |
dc.identifier.issn | 2041-1723 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/4035 | |
dc.identifier.eissn | 2041-1723 | |
dc.identifier.doi | 10.1038/ncomms11942 | |
dc.description.abstract | Receptor tyrosine kinases (RTKs) and integrins cooperate to stimulate cell migration and tumour metastasis. Here we report that an integrin influences signalling of an RTK, c-Met, from inside the cell, to promote anchorage-independent cell survival. Thus, c-Met and β1-integrin co-internalize and become progressively recruited on LC3B-positive 'autophagy-related endomembranes' (ARE). In cells growing in suspension, β1-integrin promotes sustained c-Met-dependent ERK1/2 phosphorylation on ARE. This signalling is dependent on ATG5 and Beclin1 but not on ATG13, suggesting ARE belong to a non-canonical autophagy pathway. This β1-integrin-dependent c-Met-sustained signalling on ARE supports anchorage-independent cell survival and growth, tumorigenesis, invasion and lung colonization in vivo. RTK-integrin cooperation has been assumed to occur at the plasma membrane requiring integrin 'inside-out' or 'outside-in' signalling. Our results report a novel mode of integrin-RTK cooperation, which we term 'inside-in signalling'. Targeting integrin signalling in addition to adhesion may have relevance for cancer therapy. | |
dc.format | Electronic | |
dc.format.extent | 11942 - ? | |
dc.language | eng | |
dc.language.iso | eng | |
dc.publisher | NATURE PUBLISHING GROUP | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0 | |
dc.subject | Cell Line | |
dc.subject | Fibroblasts | |
dc.subject | Animals | |
dc.subject | Humans | |
dc.subject | Mice | |
dc.subject | Hepatocyte Growth Factor | |
dc.subject | Cell Adhesion | |
dc.subject | Signal Transduction | |
dc.subject | Cell Movement | |
dc.subject | Gene Expression Regulation | |
dc.subject | Autophagy | |
dc.subject | Proto-Oncogene Proteins c-met | |
dc.subject | Carcinogenesis | |
dc.subject | Integrin beta1 | |
dc.title | Beta 1-integrin-c-Met cooperation reveals an inside-in survival signalling on autophagy-related endomembranes. | |
dc.type | Journal Article | |
dcterms.dateAccepted | 2016-05-13 | |
rioxxterms.versionofrecord | 10.1038/ncomms11942 | |
rioxxterms.licenseref.uri | https://creativecommons.org/licenses/by/4.0 | |
rioxxterms.licenseref.startdate | 2016-06-23 | |
rioxxterms.type | Journal Article/Review | |
dc.relation.isPartOf | Nature communications | |
pubs.notes | Not known | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Cancer Therapeutics | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Cancer Therapeutics/Signal Transduction & Molecular Pharmacology | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Cancer Therapeutics | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Cancer Therapeutics/Signal Transduction & Molecular Pharmacology | |
pubs.publication-status | Published | |
pubs.volume | 7 | |
pubs.embargo.terms | Not known | |
icr.researchteam | Signal Transduction & Molecular Pharmacology | |
dc.contributor.icrauthor | Hervieu Vilches, Alexia | |