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dc.contributor.authorPalomero, L
dc.contributor.authorGalván-Femenía, I
dc.contributor.authorde Cid, R
dc.contributor.authorEspín, R
dc.contributor.authorBarnes, DR
dc.contributor.authorCimba
dc.contributor.authorBlommaert, E
dc.contributor.authorGil-Gil, M
dc.contributor.authorFalo, C
dc.contributor.authorStradella, A
dc.contributor.authorOuchi, D
dc.contributor.authorRoso-Llorach, A
dc.contributor.authorViolan, C
dc.contributor.authorPeña-Chilet, M
dc.contributor.authorDopazo, J
dc.contributor.authorExtremera, AI
dc.contributor.authorGarcía-Valero, M
dc.contributor.authorHerranz, C
dc.contributor.authorMateo, F
dc.contributor.authorMereu, E
dc.contributor.authorBeesley, J
dc.contributor.authorChenevix-Trench, G
dc.contributor.authorRoux, C
dc.contributor.authorMak, T
dc.contributor.authorBrunet, J
dc.contributor.authorHakem, R
dc.contributor.authorGorrini, C
dc.contributor.authorAntoniou, AC
dc.contributor.authorLázaro, C
dc.contributor.authorPujana, MA
dc.date.accessioned2020-09-21T13:47:51Z
dc.date.issued2020-07
dc.identifier.citationiScience, 2020, 23 (7), pp. 101296 - ?
dc.identifier.issn2589-0042
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/4073
dc.identifier.eissn2589-0042
dc.identifier.doi10.1016/j.isci.2020.101296
dc.description.abstractProper immune system function hinders cancer development, but little is known about whether genetic variants linked to cancer risk alter immune cells. Here, we report 57 cancer risk loci associated with differences in immune and/or stromal cell contents in the corresponding tissue. Predicted target genes show expression and regulatory associations with immune features. Polygenic risk scores also reveal associations with immune and/or stromal cell contents, and breast cancer scores show consistent results in normal and tumor tissue. SH2B3 links peripheral alterations of several immune cell types to the risk of this malignancy. Pleiotropic SH2B3 variants are associated with breast cancer risk in BRCA1/2 mutation carriers. A retrospective case-cohort study indicates a positive association between blood counts of basophils, leukocytes, and monocytes and age at breast cancer diagnosis. These findings broaden our knowledge of the role of the immune system in cancer and highlight promising prevention strategies for individuals at high risk.
dc.formatPrint-Electronic
dc.format.extent101296 - ?
dc.languageeng
dc.language.isoeng
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0
dc.titleImmune Cell Associations with Cancer Risk.
dc.typeJournal Article
dcterms.dateAccepted2020-06-15
rioxxterms.versionofrecord10.1016/j.isci.2020.101296
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by-nc-nd/4.0
rioxxterms.licenseref.startdate2020-07
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfiScience
pubs.issue7
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Cancer Therapeutics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Cancer Therapeutics/Target Evaluation and Molecular Therapeutics
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Cancer Therapeutics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Cancer Therapeutics/Target Evaluation and Molecular Therapeutics
pubs.publication-statusPublished
pubs.volume23en_US
pubs.embargo.termsNot known
icr.researchteamTarget Evaluation and Molecular Therapeuticsen_US
dc.contributor.icrauthorGorrini, Chiaraen


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Except where otherwise noted, this item's license is described as https://creativecommons.org/licenses/by-nc-nd/4.0