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dc.contributor.authorJudson, Ien_US
dc.contributor.authorMessiou, Cen_US
dc.date.accessioned2021-01-13T12:37:21Z
dc.date.issued2021-02en_US
dc.identifier.citationGynecologic oncology reports, 2021, 35 pp. 100681 - ?en_US
dc.identifier.issn2352-5789en_US
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/4281
dc.identifier.eissn2352-5789en_US
dc.identifier.doi10.1016/j.gore.2020.100681en_US
dc.description.abstractThis is a case of recurrent intravascular leiomyomatosis in a pre-menopausal woman of African-Caribbean heritage. She presented in 2006 with multiple uterine leiomyomata, tumour invading the inferior vena cava (IVC) extending into the right atrium, and pulmonary metastases. Her initial presentation was treated surgically. On recurrence she was treated by oestrogen suppression using a combination of goserelin and letrozole, with a substantial response. She subsequently reported further regression of disease following exposure to strong sunlight enabling her to discontinue oestrogen suppression without relapse. The hypothesis is that the benefit was due to vitamin D. The role of hypovitaminosis D in the pathogenesis of uterine leiomyomata is discussed, including epidemiology data demonstrating a link between ethnicity and risk and the proven mechanisms by which vitamin D controls oestrogen and progesterone receptor expression and influences other signalling pathways involved in the pathogenesis of leiomyomas. Data indicating the intermediate malignancy nature of intravascular leiomyomatosis, are discussed. We are not aware of other reports indicating a link between intravascular leiomyomatosis and a lack of vitamin D.en_US
dc.formatElectronic-eCollectionen_US
dc.format.extent100681 - ?en_US
dc.languageengen_US
dc.language.isoengen_US
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/en_US
dc.titleVitamin D deficiency in the pathogenesis of leiomyoma and intravascular leiomyomatosis: A case report and review of the literature.en_US
dc.typeJournal Article
dcterms.dateAccepted2020-12-06en_US
rioxxterms.versionofrecord10.1016/j.gore.2020.100681en_US
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by-nc-nd/4.0en_US
rioxxterms.licenseref.startdate2021-02en_US
rioxxterms.typeJournal Article/Reviewen_US
dc.relation.isPartOfGynecologic oncology reportsen_US
pubs.notesNot knownen_US
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies/Sarcoma Clinical Trials
pubs.publication-statusAccepteden_US
pubs.volume35en_US
pubs.embargo.termsNot knownen_US
icr.researchteamSarcoma Clinical Trialsen_US
dc.contributor.icrauthorMessiou, Christinaen_US
dc.contributor.icrauthorJudson, Ianen_US


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