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dc.contributor.authorDemetri, GDen_US
dc.contributor.authorAntonescu, CRen_US
dc.contributor.authorBjerkehagen, Ben_US
dc.contributor.authorBovée, JVMGen_US
dc.contributor.authorBoye, Ken_US
dc.contributor.authorChacón, Men_US
dc.contributor.authorDei Tos, APen_US
dc.contributor.authorDesai, Jen_US
dc.contributor.authorFletcher, JAen_US
dc.contributor.authorGelderblom, Hen_US
dc.contributor.authorGeorge, Sen_US
dc.contributor.authorGronchi, Aen_US
dc.contributor.authorHaas, RLen_US
dc.contributor.authorHindi, Nen_US
dc.contributor.authorHohenberger, Pen_US
dc.contributor.authorJoensuu, Hen_US
dc.contributor.authorJones, RLen_US
dc.contributor.authorJudson, Ien_US
dc.contributor.authorKang, Y-Ken_US
dc.contributor.authorKawai, Aen_US
dc.contributor.authorLazar, AJen_US
dc.contributor.authorLe Cesne, Aen_US
dc.contributor.authorMaestro, Ren_US
dc.contributor.authorMaki, RGen_US
dc.contributor.authorMartín, Jen_US
dc.contributor.authorPatel, Sen_US
dc.contributor.authorPenault-Llorca, Fen_US
dc.contributor.authorPremanand Raut, Cen_US
dc.contributor.authorRutkowski, Pen_US
dc.contributor.authorSafwat, Aen_US
dc.contributor.authorSbaraglia, Men_US
dc.contributor.authorSchaefer, I-Men_US
dc.contributor.authorShen, Len_US
dc.contributor.authorSerrano, Cen_US
dc.contributor.authorSchöffski, Pen_US
dc.contributor.authorStacchiotti, Sen_US
dc.contributor.authorSundby Hall, Ken_US
dc.contributor.authorTap, WDen_US
dc.contributor.authorThomas, DMen_US
dc.contributor.authorTrent, Jen_US
dc.contributor.authorValverde, Cen_US
dc.contributor.authorvan der Graaf, WTAen_US
dc.contributor.authorvon Mehren, Men_US
dc.contributor.authorWagner, Aen_US
dc.contributor.authorWardelmann, Een_US
dc.contributor.authorNaito, Yen_US
dc.contributor.authorZalcberg, Jen_US
dc.contributor.authorBlay, J-Yen_US
dc.date.accessioned2021-01-13T12:45:25Z
dc.date.issued2020-11en_US
dc.identifier.citationAnnals of oncology : official journal of the European Society for Medical Oncology, 2020, 31 (11), pp. 1506 - 1517en_US
dc.identifier.issn0923-7534en_US
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/4282
dc.identifier.eissn1569-8041en_US
dc.identifier.doi10.1016/j.annonc.2020.08.2232en_US
dc.description.abstractSarcomas are a heterogeneous group of malignancies with mesenchymal lineage differentiation. The discovery of neurotrophic tyrosine receptor kinase (NTRK) gene fusions as tissue-agnostic oncogenic drivers has led to new personalized therapies for a subset of patients with sarcoma in the form of tropomyosin receptor kinase (TRK) inhibitors. NTRK gene rearrangements and fusion transcripts can be detected with different molecular pathology techniques, while TRK protein expression can be demonstrated with immunohistochemistry. The rarity and diagnostic complexity of NTRK gene fusions raise a number of questions and challenges for clinicians. To address these challenges, the World Sarcoma Network convened two meetings of expert adult oncologists and pathologists and subsequently developed this article to provide practical guidance on the management of patients with sarcoma harboring NTRK gene fusions. We propose a diagnostic strategy that considers disease stage and histologic and molecular subtypes to facilitate routine testing for TRK expression and subsequent testing for NTRK gene fusions.en_US
dc.formatPrint-Electronicen_US
dc.format.extent1506 - 1517en_US
dc.languageengen_US
dc.language.isoengen_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_US
dc.subjectHumansen_US
dc.subjectSarcomaen_US
dc.subjectReceptor, trkAen_US
dc.subjectTropomyosinen_US
dc.subjectOncogene Proteins, Fusionen_US
dc.subjectProtein Kinase Inhibitorsen_US
dc.subjectGene Fusionen_US
dc.subjectAdulten_US
dc.titleDiagnosis and management of tropomyosin receptor kinase (TRK) fusion sarcomas: expert recommendations from the World Sarcoma Network.en_US
dc.typeJournal Article
dcterms.dateAccepted2020-08-21en_US
rioxxterms.versionofrecord10.1016/j.annonc.2020.08.2232en_US
rioxxterms.licenseref.startdate2020-11en_US
rioxxterms.typeJournal Article/Reviewen_US
dc.relation.isPartOfAnnals of oncology : official journal of the European Society for Medical Oncologyen_US
pubs.issue11en_US
pubs.notesNot knownen_US
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies/Sarcoma Clinical Trials
pubs.publication-statusPublisheden_US
pubs.volume31en_US
pubs.embargo.termsNot knownen_US
icr.researchteamSarcoma Clinical Trialsen_US
dc.contributor.icrauthorJudson, Ianen_US


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Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by/4.0/