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dc.contributor.authorBiondo, A
dc.contributor.authorPal, A
dc.contributor.authorRiisnaes, R
dc.contributor.authorShinde, R
dc.contributor.authorTiu, C
dc.contributor.authorLockie, F
dc.contributor.authorBaker, C
dc.contributor.authorBertan, C
dc.contributor.authorCrespo, M
dc.contributor.authorFerreira, A
dc.contributor.authorPereira, R
dc.contributor.authorFigueiredo, I
dc.contributor.authorMiranda, S
dc.contributor.authorGurel, B
dc.contributor.authorCarreira, S
dc.contributor.authorBanerji, U
dc.contributor.authorde Bono, J
dc.contributor.authorLopez, J
dc.contributor.authorTunariu, N
dc.contributor.authorMinchom, A
dc.date.accessioned2021-03-08T16:02:07Z
dc.date.available2021-03-08T16:02:07Z
dc.date.issued2021-01-11
dc.identifier.citationCancer treatment and research communications, 2021, 27 pp. 100309 - ?
dc.identifier.issn2468-2942
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/4402
dc.identifier.eissn2468-2942
dc.identifier.doi10.1016/j.ctarc.2021.100309
dc.description.abstractEarly-phase cancer clinical trials are becoming increasingly accessible for patients with advanced cancer who have exhausted standard treatment options and later phase trial options. Many of these trials mandate research tissue biopsies. Research biopsies have been perceived as ethically fraught due to the perception of potential coercion of vulnerable human subjects. We performed an audit of two years of practice to assess the safety of ultrasound (US)-guided research biopsies, and to look at the yield of a simultaneous tumour next-generation sequencing (NGS) and immunohistochemistry (IHC) molecular characterisation programme. We show that in our institution, US-guided research biopsies were safe, produced adequate tumour content and in a selected subset who underwent in-house NGS sequencing, showed a high rate of actionable mutations with 30% having a Tier 1 variant. Nevertheless, these research biopsies may only provide direct benefit for a minority of patients and we conclude with a reflection on the importance of obtaining truly informed consent.
dc.formatPrint-Electronic
dc.format.extent100309 - ?
dc.languageeng
dc.language.isoeng
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0
dc.titleResearch Related Tumour Biopsies in Early-Phase Trials with Simultaneous Molecular Characterisation - a Single Unit Experience.
dc.typeJournal Article
dcterms.dateAccepted2021-01-08
rioxxterms.versionVoR
rioxxterms.versionofrecord10.1016/j.ctarc.2021.100309
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by-nc-nd/4.0
rioxxterms.licenseref.startdate2021-01-11
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfCancer treatment and research communications
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies/Clinical Pharmacology – Adaptive Therapy
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies/Clinical Pharmacology – Adaptive Therapy
pubs.publication-statusPublished
pubs.volume27
pubs.embargo.termsNot known
icr.researchteamClinical Pharmacology – Adaptive Therapy
icr.researchteamClinical Pharmacology – Adaptive Therapyen_US
dc.contributor.icrauthorBanerji, Udaien


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Except where otherwise noted, this item's license is described as https://creativecommons.org/licenses/by-nc-nd/4.0