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dc.contributor.authorManickavasagar, T
dc.contributor.authorYuan, W
dc.contributor.authorCarreira, S
dc.contributor.authorGurel, B
dc.contributor.authorMiranda, S
dc.contributor.authorFerreira, A
dc.contributor.authorCrespo, M
dc.contributor.authorRiisnaes, R
dc.contributor.authorBaker, C
dc.contributor.authorO'Brien, M
dc.contributor.authorBhosle, J
dc.contributor.authorPopat, S
dc.contributor.authorBanerji, U
dc.contributor.authorLopez, J
dc.contributor.authorde Bono, J
dc.contributor.authorMinchom, A
dc.date.accessioned2021-06-03T09:39:46Z
dc.date.available2021-06-03T09:39:46Z
dc.date.issued2021-04-09
dc.identifierhttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000638291500001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=d4b848928d1c3e5c86d298abb68475f9
dc.identifierARTN LMT48
dc.identifier.citationLUNG CANCER MANAGEMENT, 2021, pp. ? - ? (12)
dc.identifier.issn1758-1966
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/4597
dc.identifier.eissn1758-1974
dc.identifier.doi10.2217/lmt-2020-0031
dc.description.abstractAIM: We explore HER3 expression in lung adenocarcinoma (adeno-NSCLC) and identify potential mechanisms of HER3 expression. MATERIALS & METHODS: Tumor samples from 45 patients with adeno-NSCLC were analyzed. HER3 and HER2 expression were identified using immunohistochemistry and bioinformatic interrogation of The Cancer Genome Atlas (TCGA). RESULTS: HER3 was highly expressed in 42.2% of cases. ERBB3 copy number did not account for HER3 overexpression. Bioinformatic analysis of TCGA demonstrated that MEK activity score (a surrogate of functional signaling) did not correlate with HER3 ligands. ERBB3 RNA expression levels were significantly correlated with MEK activity after adjusting for EGFR expression. CONCLUSION: HER3 expression is common and is a potential therapeutic target by virtue of frequent overexpression and functional downstream signaling.
dc.format.extent? - ? (12)
dc.languageeng
dc.language.isoeng
dc.publisherFUTURE MEDICINE LTD
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0
dc.subjectScience & Technology
dc.subjectLife Sciences & Biomedicine
dc.subjectRespiratory System
dc.subjectERBB3
dc.subjectHER3
dc.subjectMEK
dc.subjectNSCLC
dc.titleHER3 expression and MEK activation in non-small-cell lung carcinoma.
dc.typeJournal Article
dcterms.dateAccepted2021-02-22
rioxxterms.versionVoR
rioxxterms.versionofrecord10.2217/lmt-2020-0031
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by-nc-nd/4.0
rioxxterms.licenseref.startdate2021-04-09
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfLUNG CANCER MANAGEMENT
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies/Clinical Pharmacology – Adaptive Therapy
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies/Thoracic Oncology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies/Thoracic Oncology/Thoracic Oncology (hon.)
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies/Clinical Pharmacology – Adaptive Therapy
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies/Thoracic Oncology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies/Thoracic Oncology/Thoracic Oncology (hon.)
pubs.publication-statusPublished
pubs.embargo.termsNot known
icr.researchteamClinical Pharmacology – Adaptive Therapy
icr.researchteamThoracic Oncology
icr.researchteamClinical Pharmacology – Adaptive Therapy
icr.researchteamThoracic Oncology
dc.contributor.icrauthorCarreira, Suzanne
dc.contributor.icrauthorGurel, Bora
dc.contributor.icrauthorMiranda, Susana
dc.contributor.icrauthorBanerji, Udai
dc.contributor.icrauthorDe Bono, Johann
dc.contributor.icrauthorMinchom, Anna


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