dc.contributor.author | Gounder, M | |
dc.contributor.author | Abdul Razak, AR | |
dc.contributor.author | Gilligan, AM | |
dc.contributor.author | Leong, H | |
dc.contributor.author | Ma, X | |
dc.contributor.author | Somaiah, N | |
dc.contributor.author | Chawla, SP | |
dc.contributor.author | Martin-Broto, J | |
dc.contributor.author | Grignani, G | |
dc.contributor.author | Schuetze, SM | |
dc.contributor.author | Vincenzi, B | |
dc.contributor.author | Wagner, AJ | |
dc.contributor.author | Chmielowski, B | |
dc.contributor.author | Jones, RL | |
dc.contributor.author | Shah, J | |
dc.contributor.author | Shacham, S | |
dc.contributor.author | Kauffman, M | |
dc.contributor.author | Riedel, RF | |
dc.contributor.author | Attia, S | |
dc.date.accessioned | 2021-07-01T14:55:58Z | |
dc.date.available | 2021-07-01T14:55:58Z | |
dc.date.issued | 2021-04-15 | |
dc.identifier.citation | Future oncology (London, England), 2021 | |
dc.identifier.issn | 1479-6694 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/4657 | |
dc.identifier.eissn | 1744-8301 | |
dc.identifier.doi | 10.2217/fon-2021-0284 | |
dc.description.abstract | Objective: Compare health-related quality of life (HRQoL) of selinexor versus placebo in patients with dedifferentiated liposarcoma. Materials & methods: HRQoL was assessed at baseline and day 1 of each cycle using the European Organization for Research and Treatment of Cancer 30-item core quality of life questionnaire. Results were reported from baseline to day 169 (where exposure to treatment was maximized while maintaining adequate sample size). Results: Pain scores worsened for placebo versus selinexor across all postbaseline visits, although differences in HRQoL at some visits were not significant. Other domains did not exhibit significant differences between arms; however, scores in both arms deteriorated over time. Conclusion: Patients treated with selinexor reported lower rates and slower worsening of pain compared with patients who received placebo. | |
dc.format | Print-Electronic | |
dc.language | eng | |
dc.language.iso | eng | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0 | |
dc.title | Health-related quality of life and pain with selinexor in patients with advanced dedifferentiated liposarcoma. | |
dc.type | Journal Article | |
dcterms.dateAccepted | 2021-03-31 | |
rioxxterms.version | VoR | |
rioxxterms.versionofrecord | 10.2217/fon-2021-0284 | |
rioxxterms.licenseref.uri | https://creativecommons.org/licenses/by/4.0 | |
rioxxterms.licenseref.startdate | 2021-04-15 | |
rioxxterms.type | Journal Article/Review | |
dc.relation.isPartOf | Future oncology (London, England) | |
pubs.notes | Not known | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Clinical Studies | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Clinical Studies/Sarcoma Clinical Trials (R Jones) | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Clinical Studies/Sarcoma Clinical Trials (R Jones)/Sarcoma Clinical Trials (R Jones) (hon.) | |
pubs.organisational-group | /ICR/Primary Group/Royal Marsden Clinical Units | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Clinical Studies | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Clinical Studies/Sarcoma Clinical Trials (R Jones) | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Clinical Studies/Sarcoma Clinical Trials (R Jones)/Sarcoma Clinical Trials (R Jones) (hon.) | |
pubs.organisational-group | /ICR/Primary Group/Royal Marsden Clinical Units | |
pubs.publication-status | Published | |
pubs.embargo.terms | Not known | |
icr.researchteam | Sarcoma Clinical Trials (R Jones) | |
icr.researchteam | Sarcoma Clinical Trials (R Jones) | en_US |
dc.contributor.icrauthor | Jones, Robin | |