dc.contributor.author | Tree, A | |
dc.contributor.author | Griffin, C | |
dc.contributor.author | Syndikus, I | |
dc.contributor.author | Birtle, A | |
dc.contributor.author | Choudhury, A | |
dc.contributor.author | Graham, J | |
dc.contributor.author | Ferguson, C | |
dc.contributor.author | Khoo, V | |
dc.contributor.author | Malik, Z | |
dc.contributor.author | O'Sullivan, J | |
dc.contributor.author | Panades, M | |
dc.contributor.author | Parker, C | |
dc.contributor.author | Rimmer, Y | |
dc.contributor.author | Scrase, C | |
dc.contributor.author | Staffurth, J | |
dc.contributor.author | Dearnaley, D | |
dc.contributor.author | Hall, E | |
dc.contributor.author | CHHiP investigators, | |
dc.date.accessioned | 2022-01-12T15:09:34Z | |
dc.date.available | 2022-01-12T15:09:34Z | |
dc.date.issued | 2022-06-01 | |
dc.identifier.citation | International Journal of Radiation Oncology*Biology*Physics, 2022 | |
dc.identifier.issn | 0360-3016 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/4955 | |
dc.identifier.doi | 10.1016/j.ijrobp.2021.12.160 | |
dc.identifier.doi | 10.1016/j.ijrobp.2021.12.160 | |
dc.description.abstract | PURPOSE: CHHiP is a randomized trial evaluating moderately hypofractionated radiation therapy for treatment of localized prostate cancer. Of all participants, 97% of them had concurrent short-course hormone therapy (HT), either luteinizing hormone-releasing hormone analog (LHRHa) or 150 mg of bicalutamide daily. This exploratory analysis compares efficacy and side effects in a nonrandomized comparison. METHODS AND MATERIALS: In our study, 2700 patients received LHRHa and 403 received bicalutamide. The primary endpoint was biochemical/clinical failure. Groups were compared with Cox regression adjusted for various prognostic factors and stratified by radiation therapy dose. A key secondary endpoint was erectile dysfunction (ED) assessed by clinicians (using scores from Late Effects on Normal Tissues: Subjective/Objective/Management [LENT-SOM] subjective erectile function for vaginal penetration) and patients (single items within the University of California-Los Angeles Prostate Cancer Index [UCLA PCI] and Expanded Prostate Cancer Index Composite [EPIC]-50 questionnaires) at 2 years and compared between HT regimens by χ2 trend test. RESULTS: Bicalutamide patients were significantly younger (median 67 vs 69 years LHRHa). Median follow-up was 9.3 years. There was no difference in biochemical or clinical failure with an adjusted hazard ratio or 0.97 (95% confidence interval, 0.77-1.23; P = .8). At 2 years, grade ≥2 LENT-SOM ED was reported in significantly more LHRHa patients (313 out of 590; 53%) versus bicalutamide (17 out of 68; 25%) (P < .0001). There were no differences in ED seen with UCLA-PCI and EPIC-50 questionnaires. CONCLUSIONS: In this nonrandomized comparison, there was no evidence of a difference in efficacy according to type of HT received. Bicalutamide preserved clinician assessed (LENT-SOM) erectile function at 2 years but patient-reported outcomes were similar between groups. | |
dc.language.iso | eng | |
dc.publisher | ELSEVIER SCIENCE INC | |
dc.rights.uri | http://www.rioxx.net/licenses/all-rights-reserved | |
dc.title | Nonrandomized Comparison of Efficacy and Side Effects of Bicalutamide Compared With Luteinizing Hormone-Releasing Hormone (LHRH) Analogs in Combination With Radiation Therapy in the CHHiP Trial. | |
dc.type | Journal Article | |
dcterms.dateAccepted | 2021-12-24 | |
rioxxterms.version | AM | |
rioxxterms.versionofrecord | 10.1016/j.ijrobp.2021.12.160 | |
dc.relation.isPartOf | International Journal of Radiation Oncology*Biology*Physics | |
pubs.notes | Not known | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Clinical Studies | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Clinical Studies/Clinical Trials & Statistics Unit | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Closed research teams | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Closed research teams/Clinical Academic Radiotherapy (Dearnaley) | |
pubs.organisational-group | /ICR/Primary Group/Royal Marsden Clinical Units | |
pubs.publication-status | Published | |
pubs.embargo.terms | Not known | |
icr.researchteam | Clinical Trials & Statistics Unit | |
icr.researchteam | Clinical Academic Radiotherapy (Dearnaley) | |
dc.contributor.icrauthor | Griffin, Clare | |
dc.contributor.icrauthor | Dearnaley, David | |
dc.contributor.icrauthor | Hall, Emma | |