Browsing Clinical Studies by author "Zelent, Arthur Zygmunt"
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Benzodithiophenes potentiate differentiation of acute promyelocytic leukemia cells by lowering the threshold for ligand-mediated corepressor/coactivator exchange with retinoic acid receptor alpha and enhancing changes in all-trans-retinoic acid-regulated gene expression.
Xu, K; Guidez, F; Glasow, A; Chung, D; Petrie, K; Stegmaier, K; Wang, K-K; Zhang, J; Jing, Y; Zelent, A; Waxman, S (2005-09)Differentiation induction is an effective therapy for acute promyelocytic leukemia (APL), which dramatically responds to all-trans-retinoic acid (ATRA). Recent studies have indicated that combinatorial use of retinoid and ...