Browsing Clinical Studies by author "Gonzalez de Castro, David"

Now showing items 1-4 of 4

    • Efficient Genotyping of KRAS Mutant Non-Small Cell Lung Cancer Using a Multiplexed Droplet Digital PCR Approach. 

      Pender, A; Garcia-Murillas, I; Rana, S; Cutts, RJ; Kelly, G; Fenwick, K; Kozarewa, I; Gonzalez de Castro, D; Bhosle, J; O'Brien, M; Turner, NC; Popat, S; Downward, J (2015-01)
      Droplet digital PCR (ddPCR) can be used to detect low frequency mutations in oncogene-driven lung cancer. The range of KRAS point mutations observed in NSCLC necessitates a multiplex approach to efficient mutation detection ...

    • p.(L576P) -KIT mutation in GIST: Favorable prognosis and sensitive to imatinib? 

      Noujaim, J; Gonzalez, D; Thway, K; Jones, RL; Judson, I (2016-05)
      Exon 11 KIT mutations are found in a majority of gastrointestinal stromal tumors (GIST) and are usually predictive of response to imatinib, a KIT, PDGFRA and ABL inhibitor. Exon 11 mutations with poor sensitivity to imatinib ...

    • Prognostic role of the LCS6 KRAS variant in locally advanced rectal cancer: results of the EXPERT-C trial. 

      Sclafani, F; Chau, I; Cunningham, D; Peckitt, C; Lampis, A; Hahne, JC; Braconi, C; Tabernero, J; Glimelius, B; Cervantes, A; Begum, R; Gonzalez De Castro, D; Hulkki Wilson, S; Eltahir, Z; Wotherspoon, A; Tait, D; Brown, G; Oates, J; Valeri, N (2015-09)
      <h4>Background</h4>Lethal-7 (let-7) is a tumour suppressor miRNA which acts by down-regulating several oncogenes including KRAS. A single-nucleotide polymorphism (rs61764370, T > G base substitution) in the let-7 complementary ...

    • Sequence variation in mature microRNA-608 and benefit from neo-adjuvant treatment in locally advanced rectal cancer patients. 

      Sclafani, F; Chau, I; Cunningham, D; Lampis, A; Hahne, JC; Ghidini, M; Lote, H; Zito, D; Tabernero, J; Glimelius, B; Cervantes, A; Begum, R; De Castro, DG; Wilson, SH; Peckitt, C; Eltahir, Z; Wotherspoon, A; Tait, D; Brown, G; Oates, J; Braconi, C; Valeri, N (2016-09)
      Single nucleotide polymorphisms (SNPs) in microRNA genes have been associated with colorectal cancer (CRC) risk, survival and response to treatment. Conflicting results are available on the association between rs4919510, ...