Now showing items 1-3 of 3

    • FGFR1 Expression and Role in Migration in Low and High Grade Pediatric Gliomas. 

      Egbivwie, N; Cockle, JV; Humphries, M; Ismail, A; Esteves, F; Taylor, C; Karakoula, K; Morton, R; Warr, T; Short, SC; Brüning-Richardson, A (2019-01)
      The heterogeneous and invasive nature of pediatric gliomas poses significant treatment challenges, highlighting the importance of identifying novel chemotherapeutic targets. Recently, recurrent Fibroblast growth factor ...
    • Intravenous delivery of oncolytic reovirus to brain tumor patients immunologically primes for subsequent checkpoint blockade. 

      Samson, A; Scott, KJ; Taggart, D; West, EJ; Wilson, E; Nuovo, GJ; Thomson, S; Corns, R; Mathew, RK; Fuller, MJ; Kottke, TJ; Thompson, JM; Ilett, EJ; Cockle, JV; van Hille, P; Sivakumar, G; Polson, ES; Turnbull, SJ; Appleton, ES; Migneco, G; Rose, AS; Coffey, MC; Beirne, DA; Collinson, FJ; Ralph, C; Alan Anthoney, D; Twelves, CJ; Furness, AJ; Quezada, SA; Wurdak, H; Errington-Mais, F; Pandha, H; Harrington, KJ; Selby, PJ; Vile, RG; Griffin, SD; Stead, LF; Short, SC; Melcher, AA (2018-01)
      Immune checkpoint inhibitors, including those targeting programmed cell death protein 1 (PD-1), are reshaping cancer therapeutic strategies. Evidence suggests, however, that tumor response and patient survival are determined ...
    • Oncolytic Herpes Simplex Virus Inhibits Pediatric Brain Tumor Migration and Invasion. 

      Cockle, JV; Brüning-Richardson, A; Scott, KJ; Thompson, J; Kottke, T; Morrison, E; Ismail, A; Carcaboso, AM; Rose, A; Selby, P; Conner, J; Picton, S; Short, S; Vile, R; Melcher, A; Ilett, E (2017-06)
      Pediatric high-grade glioma (pHGG) and diffuse intrinsic pontine glioma (DIPG) are invasive tumors with poor survival. Oncolytic virotherapy, initially devised as a direct cytotoxic treatment, is now also known to act via ...