Browsing Clinical Studies by publication type "Thesis or Dissertation"

Now showing items 21-26 of 26

    • Prostate specific membrane antigen and DNA damage repair in advanced prostate cancer 

      Sheehan, B (Institute of Cancer Research (University Of London), 2022-03-31)
      Identification and implementation of novel therapeutic strategies for advanced prostate cancer (PCa) remains an urgent, unmet clinical need. Prostate Specific Membrane Antigen (PSMA), a PCa biomarker, is currently being ...

    • The role of cancer-associated fibroblasts in altering signal transduction and drug resistance in KRAS mutated cancers 

      Banerji U; Lau, R; Banerji, U (Institute of Cancer Research (University Of London), 2023-01-04)
      KRAS is commonly mutated in solid tumours but effective treatment is limited due to resistance. Cancer-associated fibroblasts (CAFs) are a key tumour microenvironment component but how it interacts with KRAS mutant-cancer ...

    • Targeting androgen receptor splicing in lethal prostate cancer 

      de Bono, J; Paschalis, A (Institute of Cancer Research (University Of London), 2021-04-30)
      Over the past decade, androgen receptor (AR) directed therapies such as abiraterone and enzalutamide have become the standard of care for treating advanced prostate cancer, improving both progression-free and overall ...

    • Targeting DNA damage response in oesophagogastric cancers 

      Starling N; Cartwright, E; Starling, N (Institute of Cancer Research (University Of London), 2023-05-30)
      A subset of patients with oesphophagogastric (OG) adenocarcinomas are characterised by homologous recombination repair deficiency (HRD), providing the rationale for poly (ADP-ribose) polymerase inhibitor (PARPi) therapy ...

    • Targeting the inflammatory response in advanced prostate cancer 

      De Bono J; Guo, WY; De Bono, J (Institute of Cancer Research (University Of London), 2024-05-20)
      Prostate cancer is a leading cause of male cancer mortality. Despite inflammation being implicated in prostate cancer initiation and progression, patient outcomes have been minimally impacted by immunotherapies that have ...

    • Utilising novel therapies in the treatment of gastrointestinal cancers 

      Starling N; Turkes, F; Starling, N (Institute of Cancer Research (University Of London), 2023-05-04)
      Background: Gastrointestinal (GI) malignancies are common and frequently lethal diseases. For most, treatment options revolve around chemotherapy where efficacy beyond second line is negligible, and toxicity is high. Novel ...