Browsing Clinical Studies by author "Popat, Sanjay"
Now showing items 41-45 of 45
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A tailored approach to horizon scanning for cancer medicines.
Soon, JA; To, YH; Alexander, M; Trapani, K; Ascierto, PA; et al. (ELSEVIER SCI LTD, 2023-12-01)BACKGROUND: Horizon scanning (HS) is the systematic identification of emerging therapies to inform policy and decision-makers. We developed an agile and tailored HS methodology that combined multi-criteria decision analysis ... -
The National Lung Matrix Trial: translating the biology of stratification in advanced non-small-cell lung cancer.
Middleton, G; Crack, LR; Popat, S; Swanton, C; Hollingsworth, SJ; et al. (2015-12)Background The management of NSCLC has been transformed by stratified medicine. The National Lung Matrix Trial (NLMT) is a UK-wide study exploring the activity of rationally selected biomarker/targeted therapy combinatio ... -
Transportability of Overall Survival Estimates From US to Canadian Patients With Advanced Non-Small Cell Lung Cancer With Implications for Regulatory and Health Technology Assessment.
Ramagopalan, SV; Popat, S; Gupta, A; Boyne, DJ; Lockhart, A; et al. (AMER MEDICAL ASSOC, 2022-11-01)IMPORTANCE: The external validity of survival outcomes derived from clinical practice data from US patients with advanced non-small cell lung cancer (NSCLC) is not known and is of potential importance because it may be ... -
Tyrosine Kinase Inhibitor Activity in Patients with NSCLC Harboring Uncommon EGFR Mutations: A Retrospective International Cohort Study (UpSwinG).
Popat, S; Hsia, T-C; Hung, J-Y; Jung, HA; Shih, J-Y; et al.<h4>Background</h4>Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR TKIs) are standard of care for patients with EGFR mutation-positive non-small-cell lung cancer (NSCLC) with common mutations (Del19 or ... -
Y disruption, autosomal hypomethylation and poor male lung cancer survival.
Willis-Owen, SAG; Domingo-Sabugo, C; Starren, E; Liang, L; Freidin, MB; et al. (2021-06-14)Lung cancer is the most frequent cause of cancer death worldwide. It affects more men than women, and men generally have worse survival outcomes. We compared gene co-expression networks in affected and unaffected lung ...