dc.contributor.author | Schut, A-RW | |
dc.contributor.author | Lidington, E | |
dc.contributor.author | Timbergen, MJM | |
dc.contributor.author | Younger, E | |
dc.contributor.author | van der Graaf, WTA | |
dc.contributor.author | van Houdt, WJ | |
dc.contributor.author | Bonenkamp, JJ | |
dc.contributor.author | Jones, RL | |
dc.contributor.author | Grünhagen, DJ | |
dc.contributor.author | Sleijfer, S | |
dc.contributor.author | Verhoef, C | |
dc.contributor.author | Gennatas, S | |
dc.contributor.author | Husson, O | |
dc.date.accessioned | 2022-04-26T15:04:23Z | |
dc.date.available | 2022-04-26T15:04:23Z | |
dc.date.issued | 2022-01-29 | |
dc.identifier.citation | Cancers, 2022, 14 (3) | |
dc.identifier.issn | 2072-6694 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/5095 | |
dc.identifier.eissn | 2072-6694 | |
dc.identifier.eissn | 2072-6694 | |
dc.identifier.doi | 10.3390/cancers14030709 | |
dc.identifier.doi | 10.3390/cancers14030709 | |
dc.description.abstract | Sporadic desmoid-type fibromatosis (DTF) is a rare, non-metastasising soft-tissue tumour. Patients can experience a variety of disease-specific issues related to the unpredictable clinical course and aggressiveness of DTF, which negatively impacts health-related quality of life (HRQoL). These DTF-specific issues are not captured by generic HRQoL tools. A 102-item provisional DTF-specific HRQoL tool, the DTF-QoL, was previously developed. The aim of this study was to pre-test the psychometric properties of the DTF-QoL by administering it together with the EORTC Quality of Life Questionnaire Core 30 (EORTC QLQ-C30) to 236 DTF patients from the United Kingdom and the Netherlands. Construct validity and reliability were determined based on factor analysis, multi-trait scaling analysis, Cronbach's alpha, and correlations with the EORTC QLQ-C30 scales. Ninety-six items were selected, conceptualised into three symptom scales, eleven disease-impact scales and six single items, together forming the final DTF-QoL. Scaling assumptions were fully or moderately met for ten out of fourteen scales. Cronbach's alpha ranged from 0.551-0.908. Most scales of the DTF-QoL were weakly or moderately correlated with the EORTC QLQ-C30. The DTF-QoL is a promising tool capturing the whole spectrum of DTF-specific issues. Implementation of the DTF-QoL in research and clinical practice will help to personalise HRQoL measurement and clinical care for DTF patients. | |
dc.format | Electronic | |
dc.language | eng | |
dc.language.iso | eng | |
dc.publisher | MDPI | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.title | Development of a Disease-Specific Health-Related Quality of Life Questionnaire (DTF-QoL) for Patients with Desmoid-Type Fibromatosis. | |
dc.type | Journal Article | |
dcterms.dateAccepted | 2022-01-26 | |
rioxxterms.version | VoR | |
rioxxterms.versionofrecord | 10.3390/cancers14030709 | |
rioxxterms.licenseref.uri | https://creativecommons.org/licenses/by/4.0 | |
rioxxterms.licenseref.startdate | 2022-01-29 | |
dc.relation.isPartOf | Cancers | |
pubs.issue | 3 | |
pubs.notes | Not known | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Clinical Studies | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Clinical Studies/Clinical and Translational Sarcoma | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Clinical Studies/Sarcoma Clinical Trials (R Jones) | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Clinical Studies/Sarcoma Clinical Trials (R Jones)/Sarcoma Clinical Trials (R Jones) (hon.) | |
pubs.organisational-group | /ICR/Primary Group/Royal Marsden Clinical Units | |
pubs.publication-status | Published | |
pubs.volume | 14 | |
pubs.embargo.terms | Not known | |
icr.researchteam | Clinical and Translational Sarcoma | |
icr.researchteam | Sarcoma Clinical Trials (R Jones) | |
dc.contributor.icrauthor | Husson, Olga | |