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dc.contributor.authorSchut, A-RW
dc.contributor.authorLidington, E
dc.contributor.authorTimbergen, MJM
dc.contributor.authorYounger, E
dc.contributor.authorvan der Graaf, WTA
dc.contributor.authorvan Houdt, WJ
dc.contributor.authorBonenkamp, JJ
dc.contributor.authorJones, RL
dc.contributor.authorGrünhagen, DJ
dc.contributor.authorSleijfer, S
dc.contributor.authorVerhoef, C
dc.contributor.authorGennatas, S
dc.contributor.authorHusson, O
dc.date.accessioned2022-04-26T15:04:23Z
dc.date.available2022-04-26T15:04:23Z
dc.date.issued2022-01-29
dc.identifier.citationCancers, 2022, 14 (3)en
dc.identifier.issn2072-6694
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/5095
dc.identifier.eissn2072-6694en_US
dc.identifier.eissn2072-6694
dc.identifier.doi10.3390/cancers14030709en_US
dc.identifier.doi10.3390/cancers14030709
dc.description.abstractSporadic desmoid-type fibromatosis (DTF) is a rare, non-metastasising soft-tissue tumour. Patients can experience a variety of disease-specific issues related to the unpredictable clinical course and aggressiveness of DTF, which negatively impacts health-related quality of life (HRQoL). These DTF-specific issues are not captured by generic HRQoL tools. A 102-item provisional DTF-specific HRQoL tool, the DTF-QoL, was previously developed. The aim of this study was to pre-test the psychometric properties of the DTF-QoL by administering it together with the EORTC Quality of Life Questionnaire Core 30 (EORTC QLQ-C30) to 236 DTF patients from the United Kingdom and the Netherlands. Construct validity and reliability were determined based on factor analysis, multi-trait scaling analysis, Cronbach's alpha, and correlations with the EORTC QLQ-C30 scales. Ninety-six items were selected, conceptualised into three symptom scales, eleven disease-impact scales and six single items, together forming the final DTF-QoL. Scaling assumptions were fully or moderately met for ten out of fourteen scales. Cronbach's alpha ranged from 0.551-0.908. Most scales of the DTF-QoL were weakly or moderately correlated with the EORTC QLQ-C30. The DTF-QoL is a promising tool capturing the whole spectrum of DTF-specific issues. Implementation of the DTF-QoL in research and clinical practice will help to personalise HRQoL measurement and clinical care for DTF patients.en_US
dc.formatElectronicen_US
dc.languageengen_US
dc.language.isoengen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.titleDevelopment of a Disease-Specific Health-Related Quality of Life Questionnaire (DTF-QoL) for Patients with Desmoid-Type Fibromatosis.en
dc.typeJournal Article
dcterms.dateAccepted2022-01-26
rioxxterms.versionVoRen
rioxxterms.versionofrecord10.3390/cancers14030709en
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0en
rioxxterms.licenseref.startdate2022-01-29
dc.relation.isPartOfCancersen_US
pubs.issue3en_US
pubs.notesNot knownen_US
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies/Clinical and Translational Sarcoma
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies/Sarcoma Clinical Trials (R Jones)
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies/Sarcoma Clinical Trials (R Jones)/Sarcoma Clinical Trials (R Jones) (hon.)
pubs.organisational-group/ICR/Primary Group/Royal Marsden Clinical Units
pubs.publication-statusPublisheden_US
pubs.volume14en_US
pubs.embargo.termsNot knownen_US
icr.researchteamClinical and Translational Sarcoma
icr.researchteamSarcoma Clinical Trials (R Jones)
dc.contributor.icrauthorJones, Robinen_US
dc.contributor.icrauthorHusson, Olgaen_US


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Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by/4.0/