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dc.contributor.authorCastagnoli, F
dc.contributor.authorDoran, S
dc.contributor.authorLunn, J
dc.contributor.authorMinchom, A
dc.contributor.authorO'Brien, M
dc.contributor.authorPopat, S
dc.contributor.authorMessiou, C
dc.contributor.authorKoh, D-M
dc.coverage.spatialUnited States
dc.date.accessioned2022-07-13T09:16:37Z
dc.date.available2022-07-13T09:16:37Z
dc.date.issued2022-01-01
dc.identifierPONE-D-22-01786
dc.identifier.citationPLoS One, 2022, 17 (7), pp. e0270950 -en_US
dc.identifier.issn1932-6203
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/5218
dc.identifier.eissn1932-6203
dc.identifier.eissn1932-6203
dc.identifier.doi10.1371/journal.pone.0270950
dc.identifier.doi10.1371/journal.pone.0270950
dc.description.abstractINTRODUCTION: The spleen is a lymphoid organ and we hypothesize that clinical benefit to immunotherapy may present with an increase in splenic volume during treatment. The purpose of this study was to investigate whether changes in splenic volume could be observed in those showing clinical benefit versus those not showing clinical benefit to pembrolizumab treatment in non-small cell lung cancer (NSCLC) patients. MATERIALS AND METHODS: In this study, 70 patients with locally advanced or metastatic NSCLC treated with pembrolizumab; and who underwent baseline CT scan within 2 weeks before treatment and follow-up CT within 3 months after commencing immunotherapy were retrospectively evaluated. The splenic volume on each CT was segmented manually by outlining the splenic contour on every image and the total volume summated. We compared the splenic volume in those achieving a clinical benefit and those not achieving clinical benefit, using non-parametric Wilcoxon signed-rank test. Clinical benefit was defined as stable disease or partial response lasting for greater than 24 weeks. A p-value of <0.05 was considered statistically significant. RESULTS: There were 23 responders and 47 non-responders based on iRECIST criteria and 35 patients with clinical benefit and 35 without clinical benefit. There was no significant difference in the median pre-treatment volume (175 vs 187 cm3, p = 0.34), post-treatment volume (168 vs 167 cm3, p = 0.39) or change in splenic volume (-0.002 vs 0.0002 cm3, p = 0.97) between the two groups. No significant differences were also found between the splenic volume of patients with partial response, stable disease or progressive disease (p>0.017). Moreover, there was no statistically significant difference between progression-free survival and time to disease progression when the splenic volume was categorized as smaller or larger than the median pre-treatment or post-treatment volume (p>0.05). CONCLUSION: No significant differences were observed in the splenic volume of those showing clinical benefit versus those without clinical benefit to pembrolizumab treatment in NSCLC patients. CT splenic volume cannot be used as a potentially simple biomarker of response to immunotherapy.
dc.formatElectronic-eCollection
dc.format.extente0270950 -
dc.languageeng
dc.language.isoengen_US
dc.publisherPublic Library of Science (PLoS)en_US
dc.relation.ispartofPLoS One
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_US
dc.titleSplenic volume as a predictor of treatment response in patients with non-small cell lung cancer receiving immunotherapy.en_US
dc.typeJournal Article
dcterms.dateAccepted2022-06-22
dc.date.updated2022-07-13T09:12:55Z
rioxxterms.versionVoRen_US
rioxxterms.versionofrecord10.1371/journal.pone.0270950en_US
rioxxterms.licenseref.startdate2022-01-01
rioxxterms.typeJournal Article/Reviewen_US
pubs.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/35797413
pubs.issue7
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies/The Adult Drug Development Unit at the ICR and the RM
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies/Thoracic Oncology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies/Thoracic Oncology/Thoracic Oncology (hon.)
pubs.publication-statusPublished online
pubs.volume17
icr.researchteamAdult DDU ICR & RMen_US
dc.contributor.icrauthorMinchom, Anna
dc.contributor.icrauthorPopat, Sanjay
icr.provenanceDeposited by Mr Arek Surman on 2022-07-13. Deposit type is initial. No. of files: 1. Files: journal.pone.0270950.pdf


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