dc.contributor.author | Higham, CE | |
dc.contributor.author | Olsson-Brown, A | |
dc.contributor.author | Carroll, P | |
dc.contributor.author | Cooksley, T | |
dc.contributor.author | Larkin, J | |
dc.contributor.author | Lorigan, P | |
dc.contributor.author | Morganstein, D | |
dc.contributor.author | Trainer, PJ | |
dc.contributor.author | Society for Endocrinology Clinical Committee | |
dc.coverage.spatial | England | |
dc.date.accessioned | 2022-08-30T10:02:17Z | |
dc.date.available | 2022-08-30T10:02:17Z | |
dc.date.issued | 2018-07-01 | |
dc.identifier | EC-18-0068 | |
dc.identifier.citation | Endocrine Connections, 2018, 7 (7), pp. G1 - G7 | en_US |
dc.identifier.issn | 2049-3614 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/5348 | |
dc.identifier.eissn | 2049-3614 | |
dc.identifier.eissn | 2049-3614 | |
dc.identifier.doi | 10.1530/EC-18-0068 | |
dc.description.abstract | Immunotherapy treatment with checkpoint inhibitors (CPI) (CTLA-4 and PD-1 inhibitors) significantly improves survival in a number of cancers. Treatment can be limited by immune-mediated adverse effects including endocrinopathies such as hypophysitis, adrenalitis, thyroiditis and diabetes mellitus. If endocrinopathies (particularly hypocortisolemia) are not recognized early, they can be fatal. The diagnosis and management of endocrinopathies can be complicated by simultaneous multi-organ immune adverse effects. Here, we present Endocrine Emergency Guidance for the acute management of the endocrine complications of checkpoint inhibitor therapy, the first specialty-specific guidance with Endocrinology, Oncology and Acute Medicine input and endorsed by the Society for Endocrinology Clinical Committee. We present algorithms for management: endocrine assessment and management of patients in the first 24 hours who present life-threateningly unwell (CTCAE grade 3-4) and the appropriate management of mild-moderately unwell patients (CTCAE grade 1-2) presenting with features compatible with an endocrinopathy. Other important considerations in relation to hypohysitis and the maintenance of glucocorticoid therapy are discussed. | |
dc.format | Print | |
dc.format.extent | G1 - G7 | |
dc.language | eng | |
dc.language.iso | eng | en_US |
dc.publisher | BIOSCIENTIFICA LTD | en_US |
dc.relation.ispartof | Endocrine Connections | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc/4.0 | en_US |
dc.subject | Society for Endocrinology Clinical Committee | |
dc.title | SOCIETY FOR ENDOCRINOLOGY ENDOCRINE EMERGENCY GUIDANCE: Acute management of the endocrine complications of checkpoint inhibitor therapy. | en_US |
dc.type | Journal Article | |
dcterms.dateAccepted | 2018-03-27 | |
dc.date.updated | 2022-08-30T10:01:37Z | |
rioxxterms.version | VoR | en_US |
rioxxterms.versionofrecord | 10.1530/EC-18-0068 | en_US |
rioxxterms.licenseref.startdate | 2018-07-01 | |
rioxxterms.type | Journal Article/Review | en_US |
pubs.author-url | https://www.ncbi.nlm.nih.gov/pubmed/29930025 | |
pubs.issue | 7 | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Clinical Studies | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Clinical Studies/Melanoma and Kidney Cancer | |
pubs.organisational-group | /ICR/Primary Group/Royal Marsden Clinical Units | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Clinical Studies/Melanoma and Kidney Cancer/Melanoma and Kidney Cancer (hon.) | |
pubs.publication-status | Published | |
pubs.publisher-url | http://dx.doi.org/10.1530/ec-18-0068 | |
pubs.volume | 7 | |
dc.contributor.icrauthor | Larkin, James | |
icr.provenance | Deposited by Mr Arek Surman on 2022-08-30. Deposit type is initial. No. of files: 1. Files: SOCIETY FOR ENDOCRINOLOGY ENDOCRINE EMERGENCY GUIDANCE Acute management of the endocrine complications of checkpoint inhibit.pdf | |