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TORPEdO: A phase III trial of intensity-modulated proton beam therapy versus intensity-modulated radiotherapy for multi-toxicity reduction in oropharyngeal cancer.

dc.contributor.authorThomson, DJ
dc.contributor.authorCruickshank, C
dc.contributor.authorBaines, H
dc.contributor.authorBanner, R
dc.contributor.authorBeasley, M
dc.contributor.authorBetts, G
dc.contributor.authorBulbeck, H
dc.contributor.authorCharlwood, F
dc.contributor.authorChristian, J
dc.contributor.authorClarke, M
dc.contributor.authorDonnelly, O
dc.contributor.authorForan, B
dc.contributor.authorGillies, C
dc.contributor.authorGriffin, C
dc.contributor.authorHomer, JJ
dc.contributor.authorLangendijk, JA
dc.contributor.authorLee, LW
dc.contributor.authorLester, J
dc.contributor.authorLowe, M
dc.contributor.authorMcPartlin, A
dc.contributor.authorMiles, E
dc.contributor.authorNutting, C
dc.contributor.authorPalaniappan, N
dc.contributor.authorPrestwich, R
dc.contributor.authorPrice, JM
dc.contributor.authorRoberts, C
dc.contributor.authorRoe, J
dc.contributor.authorShanmugasundaram, R
dc.contributor.authorSimões, R
dc.contributor.authorThompson, A
dc.contributor.authorWest, C
dc.contributor.authorWilson, L
dc.contributor.authorWolstenholme, J
dc.contributor.authorHall, E
dc.date.accessioned2022-11-28T11:14:24Z
dc.date.available2022-11-28T11:14:24Z
dc.date.issued2022-11-01
dc.identifier.citationClinical and Translational Radiation Oncology, 2022,
dc.identifier.issn2405-6308
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/5578
dc.identifier.doi10.1016/j.ctro.2022.11.010
dc.description.abstract•There is a lack of prospective level I evidence for the use of PBT for most adult cancers including oropharyngeal squamous cell carcinoma (OPSCC).•TORPEdO is the UK's first PBT clinical trial and aims to determine the benefits of PBT for OPSCC.•Training and support has been provided before and during the trial to reduce variations of contouring and radiotherapy planning.•There is a strong translational component within TORPEdO. Imaging and physics data along with blood, tissue collection will inform future studies in refining patient selection for IMPT.
dc.languageen
dc.language.isoeng
dc.publisherELSEVIER IRELAND LTD
dc.relation.ispartofClinical and Translational Radiation Oncology
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.titleTORPEdO: A phase III trial of intensity-modulated proton beam therapy versus intensity-modulated radiotherapy for multi-toxicity reduction in oropharyngeal cancer.
dc.typeJournal Article
dcterms.dateAccepted2022-11-18
dc.date.updated2022-11-28T09:15:39Z
rioxxterms.versionVoR
rioxxterms.versionofrecord10.1016/j.ctro.2022.11.010
rioxxterms.licenseref.startdate2022-11-01
rioxxterms.typeJournal Article/Review
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies/Clinical Trials & Statistics Unit
pubs.publication-statusPublished
pubs.publisher-urlhttp://dx.doi.org/10.1016/j.ctro.2022.11.010
icr.researchteamClin Trials & Stats Unit
dc.contributor.icrauthorCruickshank, Clare
dc.contributor.icrauthorClarke, Matthew
dc.contributor.icrauthorGriffin, Clare
dc.contributor.icrauthorHall, Emma
icr.provenanceDeposited by Mrs Jessica Perry (impersonating Prof Emma Hall) on 2022-11-28. Deposit type is initial. No. of files: 1. Files: TORPEdO protocol publication_SUBMITTED 17.10.22.docx
icr.provenanceDeposited by Mr Arek Surman (impersonating Prof Emma Hall) on 2022-11-28. Deposit type is subsequent. No. of files: 1. Files: TORPEdO protocol publication_SUBMITTED 17.10.22.pdf
icr.provenanceDeposited by Mr Arek Surman (impersonating Prof Emma Hall) on 2022-11-28. Deposit type is subsequent. No. of files: 1. Files: PIIS2405630822001094.pdf


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