dc.contributor.author | Licciardello, MP | |
dc.contributor.author | Workman, P | |
dc.coverage.spatial | England | |
dc.date.accessioned | 2023-02-21T13:35:55Z | |
dc.date.available | 2023-02-21T13:35:55Z | |
dc.date.issued | 2022-12-14 | |
dc.identifier | d2md00291d | |
dc.identifier.citation | RSC Medicinal Chemistry, 2022, 13 (12), pp. 1446 - 1459 | |
dc.identifier.issn | 2632-8682 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/5696 | |
dc.identifier.eissn | 2632-8682 | |
dc.identifier.eissn | 2632-8682 | |
dc.identifier.doi | 10.1039/d2md00291d | |
dc.description.abstract | Small-molecule chemical probes are among the most important tools to study the function of proteins in cells and organisms. Regrettably, the use of weak and non-selective small molecules has generated an abundance of erroneous conclusions in the scientific literature. More recently, minimal criteria have been outlined for investigational compounds, encouraging the selection and use of high-quality chemical probes. Here, we briefly recall the milestones and key initiatives that have paved the way to this new era, illustrate examples of recent high-quality chemical probes and provide our perspective on future challenges and developments. | |
dc.format | Electronic-eCollection | |
dc.format.extent | 1446 - 1459 | |
dc.language | eng | |
dc.language.iso | eng | |
dc.publisher | ROYAL SOC CHEMISTRY | |
dc.relation.ispartof | RSC Medicinal Chemistry | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.subject | Science & Technology | |
dc.subject | Life Sciences & Biomedicine | |
dc.subject | Biochemistry & Molecular Biology | |
dc.subject | Chemistry, Medicinal | |
dc.subject | Pharmacology & Pharmacy | |
dc.subject | PROTEIN-KINASE CK2 | |
dc.subject | CONNECTIVITY MAP | |
dc.subject | SMALL MOLECULES | |
dc.subject | DRUG DISCOVERY | |
dc.subject | AMG 510 | |
dc.subject | CANCER | |
dc.subject | INHIBITION | |
dc.subject | SUMOYLATION | |
dc.subject | POTENT | |
dc.subject | OPPORTUNITIES | |
dc.title | The era of high-quality chemical probes. | |
dc.type | Journal Article | |
dcterms.dateAccepted | 2022-11-11 | |
dc.date.updated | 2023-02-21T13:35:09Z | |
rioxxterms.version | VoR | |
rioxxterms.versionofrecord | 10.1039/d2md00291d | |
rioxxterms.licenseref.startdate | 2022-12-14 | |
rioxxterms.type | Journal Article/Review | |
pubs.author-url | https://www.ncbi.nlm.nih.gov/pubmed/36545432 | |
pubs.issue | 12 | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Cancer Therapeutics | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Cancer Therapeutics/Signal Transduction & Molecular Pharmacology | |
pubs.publication-status | Published online | |
pubs.publisher-url | http://dx.doi.org/10.1039/d2md00291d | |
pubs.volume | 13 | |
icr.researchteam | Signal Trans & Mol Pharma | |
dc.contributor.icrauthor | Workman, Paul | |
icr.provenance | Deposited by Mr Arek Surman on 2023-02-21. Deposit type is initial. No. of files: 1. Files: The era of high-quality chemical probes.pdf | |