dc.contributor.author | Philipps, L | |
dc.contributor.author | Porta, N | |
dc.contributor.author | James, N | |
dc.contributor.author | Huddart, R | |
dc.contributor.author | Hafeez, S | |
dc.contributor.author | Ballas, L | |
dc.contributor.author | Hall, E | |
dc.date.accessioned | 2023-03-20T15:16:24Z | |
dc.date.available | 2023-03-20T15:16:24Z | |
dc.date.issued | 2023-02-01 | |
dc.identifier.citation | Clinical Oncology, 2023, | |
dc.identifier.issn | 0936-6555 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/5724 | |
dc.identifier.doi | 10.1016/j.clon.2023.02.005 | |
dc.description.abstract | AIMS: BC2001, a randomised trial of treatment for muscle-invasive bladder cancer, demonstrated no difference in health-related quality of life (HRQoL) or late toxicity between patients receiving radical radiotherapy with and without chemotherapy. This secondary analysis explored sex-based differences in HRQoL and toxicity. MATERIALS AND METHODS: Participants completed the Functional Assessment of Cancer Therapy Bladder (FACT-BL) HRQoL questionnaires at baseline, end of treatment, 6 months and annually until 5 years. Clinicians assessed toxicity with the Radiation Therapy Oncology Group (RTOG) and Late Effects in Normal Tissues Subjective, Objective and Management (LENT/SOM) scoring systems at the same timepoints. The impact of sex on patient-reported HRQoL was evaluated using multivariate analyses of change in FACT-BL subscores from baseline to the timepoints of interest. For clinician-reported toxicity, differences were compared by calculating the proportion of patients with grade 3-4 toxicities occurring over the follow-up period. RESULTS: For both males and females, all FACT-BL subscores had a reduction in HRQoL at the end of treatment. For males, the mean bladder cancer subscale (BLCS) score remained stable through to year 5. For females, there was a decline in BLCS from baseline at years 2 and 3 with a return to baseline at year 5. At year 3, females had a statistically significant and clinically meaningful worsening of mean BLCS score (-5.18; 95% confidence interval -8.37 to -1.99), which was not seen in males (0.24; -0.76 to 1.23). RTOG toxicity was more frequent in females than males (27% versus 16%, P = 0.027). CONCLUSION: Results suggest that female patients treated with radiotherapy ± chemotherapy for localised bladder cancer report worse treatment-related toxicity in post-treatment years 2 and 3 than males. | |
dc.language | en | |
dc.language.iso | eng | |
dc.publisher | ELSEVIER SCIENCE LONDON | |
dc.relation.ispartof | Clinical Oncology | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.title | Differences in Quality of Life and Toxicity for Male and Female Patients following Chemo(radiotherapy) for Bladder Cancer. | |
dc.type | Journal Article | |
dcterms.dateAccepted | 2023-02-07 | |
dc.date.updated | 2023-03-07T10:51:22Z | |
rioxxterms.version | AM | |
rioxxterms.versionofrecord | 10.1016/j.clon.2023.02.005 | |
rioxxterms.licenseref.startdate | 2023-02-01 | |
rioxxterms.type | Journal Article/Review | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Clinical Studies | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Clinical Studies/Clinical Trials & Statistics Unit | |
pubs.organisational-group | /ICR/Students | |
pubs.organisational-group | /ICR/Students/PhD and MPhil | |
pubs.organisational-group | /ICR/Students/PhD and MPhil/19/20 Starting Cohort | |
pubs.publication-status | Published | |
pubs.publisher-url | http://dx.doi.org/10.1016/j.clon.2023.02.005 | |
icr.researchteam | Clin Trials & Stats Unit | |
dc.contributor.icrauthor | Philipps, Lara | |
dc.contributor.icrauthor | Porta, Nuria | |
dc.contributor.icrauthor | James, Nicholas | |
dc.contributor.icrauthor | Huddart, Robert | |
dc.contributor.icrauthor | Hafeez, Shaista | |
dc.contributor.icrauthor | Hall, Emma | |
icr.provenance | Deposited by Mrs Jessica Perry (impersonating Prof Emma Hall) on 2023-03-07. Deposit type is initial. No. of files: 1. Files: Differences in quality of life and toxicity for male and female patients following chemo (radiotherapy) for bladder cancer.pdf | |