dc.contributor.author | Mahalingam, P | |
dc.contributor.author | Smith, S | |
dc.contributor.author | Lopez, J | |
dc.contributor.author | Sharma, RK | |
dc.contributor.author | Millard, T | |
dc.contributor.author | Thway, K | |
dc.contributor.author | Fisher, C | |
dc.contributor.author | Reardon, DA | |
dc.contributor.author | Jones, R | |
dc.contributor.author | Nicholson, AG | |
dc.contributor.author | Cunningham, D | |
dc.contributor.author | Welsh, L | |
dc.contributor.author | Sharma, B | |
dc.coverage.spatial | England | |
dc.date.accessioned | 2023-04-12T10:19:17Z | |
dc.date.available | 2023-04-12T10:19:17Z | |
dc.date.issued | 2023-01-01 | |
dc.identifier | 10.1177_20363613231152333 | |
dc.identifier.citation | Rare Tumors, 2023, 15 pp. 20363613231152333 - | |
dc.identifier.issn | 2036-3605 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/5748 | |
dc.identifier.eissn | 2036-3613 | |
dc.identifier.eissn | 2036-3613 | |
dc.identifier.doi | 10.1177/20363613231152333 | |
dc.description.abstract | Myxopapillary ependymoma (MPE) is a primary tumor of the central nervous system (CNS), characteristically an indolent malignancy involving the spinal conus medullaris, Filum terminale or cauda equina. We present a rare case of MPE, recurrent in the pelvic soft tissue with eventual pleural and intra-pulmonary metastasis. Refractory to repeated gross resection, adjuvant radiotherapy, platinum-based chemotherapy and temozolomide exploitation of mutant somatic BRCA1 status with the addition of a poly (ADP-ribose); polymerase inhibitor (PARPi) in a novel combination regimen with olaparib-temozolomide (OT) has achieved stable radiological disease after 10 cycles. | |
dc.format | Electronic-eCollection | |
dc.format.extent | 20363613231152333 - | |
dc.language | eng | |
dc.language.iso | eng | |
dc.publisher | SAGE PUBLICATIONS LTD | |
dc.relation.ispartof | Rare Tumors | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc/4.0 | |
dc.subject | Oncology | |
dc.subject | PARP inhibitor | |
dc.subject | ependymoma | |
dc.title | PARP inhibition utilized in combination therapy with Olaparib-Temozolomide to achieve disease stabilization in a rare case of BRCA1-mutant, metastatic myxopapillary ependymoma. | |
dc.type | Journal Article | |
dcterms.dateAccepted | 2023-01-05 | |
dc.date.updated | 2023-04-12T10:18:29Z | |
rioxxterms.version | VoR | |
rioxxterms.versionofrecord | 10.1177/20363613231152333 | |
rioxxterms.licenseref.startdate | 2023-01-01 | |
rioxxterms.type | Journal Article/Review | |
pubs.author-url | https://www.ncbi.nlm.nih.gov/pubmed/36698626 | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Clinical Studies | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Clinical Studies/Medicine (RMH Smith Cunningham) | |
pubs.organisational-group | /ICR/Primary Group/Royal Marsden Clinical Units | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Clinical Studies/Medicine (RMH Smith Cunningham)/Medicine (RMH Smith Cunningham) (hon.) | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Clinical Studies/Early Phase Drug Development | |
pubs.publication-status | Published online | |
pubs.publisher-url | http://dx.doi.org/10.1177/20363613231152333 | |
pubs.volume | 15 | |
icr.researchteam | Early Phase Drug Develop | |
icr.researchteam | Medicine (RMH) | |
dc.contributor.icrauthor | Sharma, Bhupinder | |
icr.provenance | Deposited by Mr Arek Surman on 2023-04-12. Deposit type is initial. No. of files: 1. Files: PARP inhibition utilized in combination therapy with Olaparib-Temozolomide to achieve disease stabilization in a rare case o.pdf | |