dc.contributor.author | Ratnakumaran, R | |
dc.contributor.author | Hinder, V | |
dc.contributor.author | Brand, D | |
dc.contributor.author | Staffurth, J | |
dc.contributor.author | Hall, E | |
dc.contributor.author | van As, N | |
dc.contributor.author | Tree, A | |
dc.contributor.author | PACE Trial Investigators, | |
dc.coverage.spatial | Switzerland | |
dc.date.accessioned | 2023-05-05T13:48:19Z | |
dc.date.available | 2023-05-05T13:48:19Z | |
dc.date.issued | 2023-02-17 | |
dc.identifier | ARTN 1288 | |
dc.identifier | cancers15041288 | |
dc.identifier.citation | Cancers, 2023, 15 (4), pp. 1288 - | |
dc.identifier.issn | 2072-6694 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/5781 | |
dc.identifier.eissn | 2072-6694 | |
dc.identifier.eissn | 2072-6694 | |
dc.identifier.doi | 10.3390/cancers15041288 | |
dc.description.abstract | Several studies have demonstrated the association between acute and late radiotherapy toxicity in prostate cancer using older radiotherapy techniques. However, whether this association is present with newer techniques such as stereotactic body radiotherapy (SBRT), remains unclear. We use univariable and multivariable logistic regression to analyse the association between grade 2 or worse acute gastrointestinal (GI) and genitourinary (GU) toxicities with equivalent late toxicities in patients treated with SBRT and conventional or moderately fractionated radiotherapy (CRT) within the PACE-B study. 842 patients were included in this analysis. Common Terminology Criteria for Adverse Events (CTCAE) was the primary clinician reported outcome measure used in this analysis. In univariable analysis, experiencing a grade 2+ acute GU toxicity was significantly associated with developing a grade 2+ late GU toxicity after SBRT (OR 4.63, 95% CI (2.96-7.25), p < 0.0001) and CRT (OR 2.83, 95% CI (1.69-4.71), p < 0.0001). This association remained significant in multivariable analysis. In univariable analysis, experiencing a grade 2+ acute GI toxicity was also associated with developing a grade 2+ late GI toxicity after SBRT (OR 3.67, 95% CI (1.91-7.03), p < 0.0001) and CRT (OR 4.4, 95% CI (2.04-9.47), p < 0.0001). This association also remained significant in multivariable analysis. Grade 2+ baseline GU symptoms were also associated with grade 2+ late urinary toxicity in both univariable and multivariable analysis. Overall, acute toxicity is an important predictor variable for late GU/GI toxicity after localised prostate radiotherapy using SBRT and CRT. Future work should test whether optimising symptoms pre-treatment and early intervention in those with significant acute toxicities could mitigate the development late of toxicity. | |
dc.format | Electronic | |
dc.format.extent | 1288 - | |
dc.language | eng | |
dc.language.iso | eng | |
dc.publisher | MDPI | |
dc.relation.ispartof | Cancers | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.subject | acute toxicity | |
dc.subject | gastrointestinal | |
dc.subject | genitourinary | |
dc.subject | intensity-modulated radiotherapy | |
dc.subject | late toxicity | |
dc.subject | prostate cancer | |
dc.subject | stereotactic body radiotherapy | |
dc.title | The Association between Acute and Late Genitourinary and Gastrointestinal Toxicities: An Analysis of the PACE B Study. | |
dc.type | Journal Article | |
dcterms.dateAccepted | 2023-02-11 | |
dc.date.updated | 2023-05-05T13:46:59Z | |
rioxxterms.version | VoR | |
rioxxterms.versionofrecord | 10.3390/cancers15041288 | |
rioxxterms.licenseref.startdate | 2023-02-17 | |
rioxxterms.type | Journal Article/Review | |
pubs.author-url | https://www.ncbi.nlm.nih.gov/pubmed/36831631 | |
pubs.issue | 4 | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Clinical Studies | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Clinical Studies/Clinical Trials & Statistics Unit | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Stereotactic and Precision Body Radiotherapy | |
pubs.organisational-group | /ICR/Students | |
pubs.organisational-group | /ICR/Students/PhD and MPhil | |
pubs.organisational-group | /ICR/Students/PhD and MPhil/17/18 Starting Cohort | |
pubs.publication-status | Published online | |
pubs.publisher-url | http://dx.doi.org/10.3390/cancers15041288 | |
pubs.volume | 15 | |
icr.researchteam | Stereotactic Radiother | |
icr.researchteam | Clin Trials & Stats Unit | |
dc.contributor.icrauthor | Ratnakumaran, Ragu | |
dc.contributor.icrauthor | Brand, Douglas | |
dc.contributor.icrauthor | Hall, Emma | |
icr.provenance | Deposited by Mr Arek Surman on 2023-05-05. Deposit type is initial. No. of files: 1. Files: The Association between Acute and Late Genitourinary and Gastrointestinal Toxicities An Analysis of the PACE B Study.pdf | |