dc.contributor.author | Stankunaite, R | |
dc.contributor.author | Marshall, LV | |
dc.contributor.author | Carceller, F | |
dc.contributor.author | Chesler, L | |
dc.contributor.author | Hubank, M | |
dc.contributor.author | George, SL | |
dc.coverage.spatial | Switzerland | |
dc.date.accessioned | 2023-07-07T12:34:46Z | |
dc.date.available | 2023-07-07T12:34:46Z | |
dc.date.issued | 2022-11-16 | |
dc.identifier | ARTN 957944 | |
dc.identifier.citation | Frontiers in Pediatrics, 2022, 10 pp. 957944 - | |
dc.identifier.issn | 2296-2360 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/5884 | |
dc.identifier.eissn | 2296-2360 | |
dc.identifier.eissn | 2296-2360 | |
dc.identifier.doi | 10.3389/fped.2022.957944 | |
dc.description.abstract | Circulating cell-free DNA (cfDNA) analysis has the potential to revolutionise the care of patients with cancer and is already moving towards standard of care in some adult malignancies. Evidence for the utility of cfDNA analysis in paediatric cancer patients is also accumulating. In this review we discuss the limitations of blood-based assays in patients with brain tumours and describe the evidence supporting cerebrospinal fluid (CSF) cfDNA analysis. We make recommendations for CSF cfDNA processing to aid the standardisation and technical validation of future assays. We discuss the considerations for interpretation of cfDNA analysis and highlight promising future directions. Overall, cfDNA profiling shows great potential as an adjunct to the analysis of biopsy tissue in paediatric cancer patients, with the potential to provide a genetic molecular profile of the tumour when tissue biopsy is not feasible. However, to fully realise the potential of cfDNA analysis for children with brain tumours larger prospective studies incorporating serial CSF sampling are required. | |
dc.format | Electronic-eCollection | |
dc.format.extent | 957944 - | |
dc.language | eng | |
dc.language.iso | eng | |
dc.publisher | FRONTIERS MEDIA SA | |
dc.relation.ispartof | Frontiers in Pediatrics | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.subject | CNS tumours | |
dc.subject | cancer heterogeneity | |
dc.subject | cell free DNA (cfDNA) | |
dc.subject | circulating tumour DNA (ctDNA) | |
dc.subject | liquid bioposy | |
dc.subject | molecular diagnostics | |
dc.subject | paediatric oncology | |
dc.subject | personalised medicine | |
dc.title | Liquid biopsy for children with central nervous system tumours: Clinical integration and technical considerations. | |
dc.type | Journal Article | |
dcterms.dateAccepted | 2022-10-28 | |
dc.date.updated | 2023-07-07T12:32:21Z | |
rioxxterms.version | VoR | |
rioxxterms.versionofrecord | 10.3389/fped.2022.957944 | |
rioxxterms.licenseref.startdate | 2022-11-16 | |
rioxxterms.type | Journal Article/Review | |
pubs.author-url | https://www.ncbi.nlm.nih.gov/pubmed/36467471 | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Cancer Therapeutics | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Cancer Therapeutics/Paediatric Solid Tumour Biology and Therapeutics | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Clinical Studies | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Clinical Studies/Paediatric Solid Tumour Biology and Therapeutics | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology/Paediatric Solid Tumour Biology and Therapeutics | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology/Translational Genomics | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology/Translational Genomics/Translational Genomics (hon.) | |
pubs.organisational-group | /ICR/Students | |
pubs.organisational-group | /ICR/Students/PhD and MPhil | |
pubs.organisational-group | /ICR/Students/PhD and MPhil/18/19 Starting Cohort | |
pubs.organisational-group | /ICR/Students/PhD and MPhil/14/15 Starting Cohort | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Clinical Studies/Developmental Oncology | |
pubs.publication-status | Published online | |
pubs.publisher-url | http://dx.doi.org/10.3389/fped.2022.957944 | |
pubs.volume | 10 | |
icr.researchteam | Paediatric Tumour Biology | |
icr.researchteam | Developmental Oncology | |
dc.contributor.icrauthor | Stankunaite, Reda | |
dc.contributor.icrauthor | Chesler, Louis | |
dc.contributor.icrauthor | George, Sally | |
icr.provenance | Deposited by Mr Arek Surman (impersonating Dr Sally George) on 2023-07-07. Deposit type is initial. No. of files: 1. Files: Liquid biopsy for children with central nervous system tumours Clinical integration and technical considerations.pdf | |