dc.contributor.author | Chisholm, J | |
dc.contributor.author | Mandeville, H | |
dc.contributor.author | Adams, M | |
dc.contributor.author | Minard-Collin, V | |
dc.contributor.author | Rogers, T | |
dc.contributor.author | Kelsey, A | |
dc.contributor.author | Shipley, J | |
dc.contributor.author | van Rijn, RR | |
dc.contributor.author | de Vries, I | |
dc.contributor.author | van Ewijk, R | |
dc.contributor.author | de Keizer, B | |
dc.contributor.author | Gatz, SA | |
dc.contributor.author | Casanova, M | |
dc.contributor.author | Hjalgrim, LL | |
dc.contributor.author | Firth, C | |
dc.contributor.author | Wheatley, K | |
dc.contributor.author | Kearns, P | |
dc.contributor.author | Liu, W | |
dc.contributor.author | Kirkham, A | |
dc.contributor.author | Rees, H | |
dc.contributor.author | Bisogno, G | |
dc.contributor.author | Wasti, A | |
dc.contributor.author | Wakeling, S | |
dc.contributor.author | Heenen, D | |
dc.contributor.author | Tweddle, DA | |
dc.contributor.author | Merks, JHM | |
dc.contributor.author | Jenney, M | |
dc.date.accessioned | 2024-03-07T11:33:12Z | |
dc.date.available | 2024-03-07T11:33:12Z | |
dc.date.issued | 2024-02-29 | |
dc.identifier.citation | Cancers, 2024, 16 (5), pp. 998 - 998 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/6174 | |
dc.identifier.eissn | 2072-6694 | |
dc.identifier.eissn | 2072-6694 | |
dc.identifier.doi | 10.3390/cancers16050998 | |
dc.identifier.doi | 10.3390/cancers16050998 | |
dc.description.abstract | The Frontline and Relapsed Rhabdomyosarcoma (FaR-RMS) clinical trial is an overarching, multinational study for children and adults with rhabdomyosarcoma (RMS). The trial, developed by the European Soft Tissue Sarcoma Study Group (EpSSG), incorporates multiple different research questions within a multistage design with a focus on (i) novel regimens for poor prognostic subgroups, (ii) optimal duration of maintenance chemotherapy, and (iii) optimal use of radiotherapy for local control and widespread metastatic disease. Additional sub-studies focusing on biological risk stratification, use of imaging modalities, including [18F]FDG PET-CT and diffusion-weighted MRI imaging (DWI) as prognostic markers, and impact of therapy on quality of life are described. This paper forms part of a Special Issue on rhabdomyosarcoma and outlines the study background, rationale for randomisations and sub-studies, design, and plans for utilisation and dissemination of results. | |
dc.format.extent | 998 - 998 | |
dc.language | en | |
dc.language.iso | eng | |
dc.publisher | MDPI | |
dc.relation.ispartof | Cancers | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.title | Frontline and Relapsed Rhabdomyosarcoma (FAR-RMS) Clinical Trial: A Report from the European Paediatric Soft Tissue Sarcoma Study Group (EpSSG). | |
dc.type | Journal Article | |
dcterms.dateAccepted | 2024-02-26 | |
dc.date.updated | 2024-03-01T20:48:42Z | |
rioxxterms.version | VoR | |
rioxxterms.versionofrecord | 10.3390/cancers16050998 | |
rioxxterms.licenseref.startdate | 2024-02-29 | |
rioxxterms.type | Journal Article/Review | |
pubs.issue | 5 | |
pubs.organisational-group | ICR | |
pubs.organisational-group | ICR/Primary Group | |
pubs.organisational-group | ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | ICR/Primary Group/ICR Divisions/Clinical Studies | |
pubs.organisational-group | ICR/Primary Group/ICR Divisions/Clinical Studies/Sarcoma Clinical Trials in Children and Young People | |
pubs.organisational-group | ICR/Primary Group/ICR Divisions/Molecular Pathology | |
pubs.organisational-group | ICR/Primary Group/ICR Divisions/Molecular Pathology/Sarcoma Clinical Trials in children and young people | |
pubs.organisational-group | ICR/Primary Group/Royal Marsden Clinical Units | |
pubs.organisational-group | ICR/Primary Group/ICR Divisions/Clinical Studies/Sarcoma Clinical Trials in Children and Young People/Sarcoma Clinical Trials in Children and Young People (hon.) | |
pubs.organisational-group | ICR/Primary Group/ICR Divisions/Molecular Pathology/Sarcoma Clinical Trials in children and young people/Sarcoma Clinical Trials in Children and Young People (hon.) | |
pubs.publication-status | Published online | |
pubs.publisher-url | http://dx.doi.org/10.3390/cancers16050998 | |
pubs.volume | 16 | |
dc.contributor.icrauthor | Shipley, Janet | |
icr.provenance | Deposited by Dr Julia Chisholm on 2024-03-01. Deposit type is initial. No. of files: 1. Files: cancers-16-00998FaR-RMS.pdf | |