dc.contributor.author | Grünwald, V | |
dc.contributor.author | Litière, S | |
dc.contributor.author | Young, R | |
dc.contributor.author | Messiou, C | |
dc.contributor.author | Lia, M | |
dc.contributor.author | Wardelmann, E | |
dc.contributor.author | van der Graaf, W | |
dc.contributor.author | Gronchi, A | |
dc.contributor.author | Judson, I | |
dc.contributor.author | EORTC STBSG | |
dc.date.accessioned | 2017-04-26T09:57:34Z | |
dc.date.issued | 2016-09 | |
dc.identifier.citation | European journal of cancer (Oxford, England : 1990), 2016, 64 pp. 44 - 51 | |
dc.identifier.issn | 0959-8049 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/621 | |
dc.identifier.eissn | 1879-0852 | |
dc.identifier.doi | 10.1016/j.ejca.2016.05.023 | |
dc.description.abstract | Background Anthracycline-based chemotherapy remains the mainstay of first-line treatment in metastatic or advanced soft-tissue sarcoma (STS). Age, performance status, tumour histology and tumour grade are recognised prognostic factors; however, the prognostic value of tumour response and tumour shrinkage is ill-defined.Methods Patients recruited to the European Organisation for Research and Treatment of Cancer 62012 trial with advanced intermediate or high-grade STS, who received at least one cycle of chemotherapy and one tumour assessment of response, were eligible for this study. Kaplan-Meier estimates of overall survival (OS) by tumour response were computed using a landmark approach after two, four, and six cycles of chemotherapy. The prognostic role of the kinetics of tumour response was analysed by Cox proportional hazards.Results Three hundred eighty-nine patients were included in this study. Compared to stable or responding patients, patients with progressive disease (PD) after two, four and six cycles of chemotherapy achieved a worse OS: hazard ratio [HR] 2.62 (95% confidence interval [CI] 1.72-4.00), p < 0.001; HR 2.23 (95% CI 1.4-3.56), p = 0.0001; and HR 3.16 (95% CI 1.96-5.08), p = 0.0001, respectively. However, patients with stable or responding disease achieved similar OS outcomes. Correspondingly, patients with an increase in tumour size by 10% or more correlated with a worse OS in Cox proportional hazard analysis.Conclusions No association between prognosis and amount of tumour shrinkage was detected. Interestingly, an increase in tumour size by at least 10% correlated with a worse OS, but re-defining PD as a ≥10% increase in tumour size did not translate into a better discrimination of survival outcomes for responders versus stable disease. Disease control rather than tumour response is a valuable end-point in advanced or metastatic STS receiving palliative anthracycline-based chemotherapy, supporting the use of time-to-event end-points in future STS trials. | |
dc.format | Print-Electronic | |
dc.format.extent | 44 - 51 | |
dc.language | eng | |
dc.language.iso | eng | |
dc.subject | EORTC STBSG | |
dc.subject | Humans | |
dc.subject | Sarcoma | |
dc.subject | Soft Tissue Neoplasms | |
dc.subject | Disease Progression | |
dc.subject | Anthracyclines | |
dc.subject | Antineoplastic Combined Chemotherapy Protocols | |
dc.subject | Prognosis | |
dc.subject | Tumor Burden | |
dc.subject | Proportional Hazards Models | |
dc.subject | Predictive Value of Tests | |
dc.subject | Adult | |
dc.subject | Middle Aged | |
dc.subject | Female | |
dc.subject | Male | |
dc.subject | Young Adult | |
dc.subject | Kaplan-Meier Estimate | |
dc.title | Absence of progression, not extent of tumour shrinkage, defines prognosis in soft-tissue sarcoma - An analysis of the EORTC 62012 study of the EORTC STBSG. | |
dc.type | Journal Article | |
dcterms.dateAccepted | 2016-05-17 | |
rioxxterms.versionofrecord | 10.1016/j.ejca.2016.05.023 | |
rioxxterms.licenseref.startdate | 2016-09 | |
rioxxterms.type | Journal Article/Review | |
dc.relation.isPartOf | European journal of cancer (Oxford, England : 1990) | |
pubs.notes | Not known | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Clinical Studies | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Clinical Studies/Clinical and Translational Sarcoma | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Clinical Studies/Sarcoma Clinical Trials | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Clinical Studies | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Clinical Studies/Clinical and Translational Sarcoma | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Clinical Studies/Sarcoma Clinical Trials | |
pubs.publication-status | Published | |
pubs.volume | 64 | |
pubs.embargo.terms | Not known | |
icr.researchteam | Clinical and Translational Sarcoma | en_US |
icr.researchteam | Sarcoma Clinical Trials | en_US |
dc.contributor.icrauthor | van der Graaf, Wilhelmina | |
dc.contributor.icrauthor | Judson, Ian | |
dc.contributor.icrauthor | Messiou, Christina | |