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dc.contributor.authorIyizoba-Ebozue, Z
dc.contributor.authorNicklin, E
dc.contributor.authorPrice, J
dc.contributor.authorPrestwich, R
dc.contributor.authorBrown, S
dc.contributor.authorHall, E
dc.contributor.authorLilley, J
dc.contributor.authorLowe, M
dc.contributor.authorThomson, DJ
dc.contributor.authorSlevin, F
dc.contributor.authorMurray, L
dc.contributor.authorBoele, F
dc.coverage.spatialEngland
dc.date.accessioned2024-05-20T14:17:57Z
dc.date.available2024-05-20T14:17:57Z
dc.date.issued2024-06-01
dc.identifier100241
dc.identifierS2405-6324(24)00008-8
dc.identifier.citationTechnical Innovations and Patient Support in Radiation Oncology, 2024, 30 pp. 100241 -
dc.identifier.issn2405-6324
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/6240
dc.identifier.eissn2405-6324
dc.identifier.eissn2405-6324
dc.identifier.doi10.1016/j.tipsro.2024.100241
dc.identifier.doi10.1016/j.tipsro.2024.100241
dc.description.abstractBACKGROUND: Late effects of cancer treatment, such as neurocognitive deficits and fatigue, can be debilitating. Other than head and neck-specific functional deficits such as impairments in swallowing and speech, little is known about survivorship after oropharyngeal cancer. This study examines the lived experience of fatigue and neurocognitive deficits in survivors of oropharyngeal squamous cell cancer and impact on their daily lives. METHODS: This work is part of the multicentre mixed method ROC-oN study (Radiotherapy for Oropharyngeal Cancer and impact on Neurocognition), evaluating fatigue and neurocognitive function in patients following radiotherapy +/- chemotherapy for oropharyngeal cancer and impact on quality of life. Semi-structured interviews were conducted in adults treated with radiotherapy (+/-chemotherapy) for oropharyngeal squamous cell carcinoma >/=24 months from completing treatment. Reflexive thematic analysis performed. RESULTS: 21 interviews (11 men and 10 women; median age 58 years and median time post-treatment 5 years) were conducted and analysed, yielding six themes: (1) unexpected burden of fatigue, (2) noticing changes in neurocognitive function, (3) the new normal, (4) navigating changes, (5)insufficient awareness and (6)required support. Participants described fatigue that persisted beyond the acute post-treatment period and changes in neurocognitive abilities across several domains. Paid and unpaid work, emotions and mood were impacted. Participants described navigating the new normal by adopting self-management strategies and accepting external support. They reported lack of recognition of these late effects, being poorly informed and being unprepared. Follow-up services were thought to be inadequate. CONCLUSIONS: Fatigue and neurocognitive impairment were frequently experienced by survivors of oropharyngeal cancer, at least two years after treatment. Patients felt ill-prepared for these late sequelae, highlighting opportunities for improvement of patient information and support services.
dc.formatElectronic-eCollection
dc.format.extent100241 -
dc.languageeng
dc.language.isoeng
dc.publisherElsevier BV
dc.relation.ispartofTechnical Innovations and Patient Support in Radiation Oncology
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectFatigue
dc.subjectLate effects
dc.subjectNeurocognition
dc.subjectOropharyngeal Cancer
dc.subjectQuality of Life
dc.subjectRadiotherapy
dc.title"Why am I still suffering?": Experience of long-term fatigue and neurocognitive changes in oropharyngeal cancer survivors following (chemo)radiotherapy.
dc.typeJournal Article
dcterms.dateAccepted2024-02-29
dc.date.updated2024-05-20T14:15:37Z
rioxxterms.versionVoR
rioxxterms.versionofrecord10.1016/j.tipsro.2024.100241
rioxxterms.licenseref.startdate2024-06-01
rioxxterms.typeJournal Article/Review
pubs.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/38510557
pubs.organisational-groupICR
pubs.organisational-groupICR/Primary Group
pubs.organisational-groupICR/Primary Group/ICR Divisions
pubs.organisational-groupICR/Primary Group/ICR Divisions/Clinical Studies
pubs.organisational-groupICR/Primary Group/ICR Divisions/Clinical Studies/Clinical Trials & Statistics Unit
pubs.publication-statusPublished online
pubs.publisher-urlhttp://dx.doi.org/10.1016/j.tipsro.2024.100241
pubs.volume30
icr.researchteamClin Trials & Stats Unit
dc.contributor.icrauthorHall, Emma
icr.provenanceDeposited by Mr Arek Surman on 2024-05-20. Deposit type is initial. No. of files: 1. Files: Why am I still suffering Experience of long-term fatigue and neurocognitive changes in oropharyngeal cancer survivors follow.pdf


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