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dc.contributor.authorBalyasnikova, Sen_US
dc.contributor.authorRead, Jen_US
dc.contributor.authorTait, Den_US
dc.contributor.authorWotherspoon, Aen_US
dc.contributor.authorSwift, Ien_US
dc.contributor.authorCunningham, Den_US
dc.contributor.authorTekkis, Pen_US
dc.contributor.authorBrown, Gen_US
dc.date.accessioned2017-07-19T15:17:23Z
dc.date.issued2017-02en_US
dc.identifier.citationColorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland, 2017, 19 (2), pp. 139 - 147en_US
dc.identifier.issn1462-8910en_US
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/723
dc.identifier.eissn1463-1318en_US
dc.identifier.doi10.1111/codi.13477en_US
dc.description.abstract<h4>Aim</h4>The study aimed to establish the oncological outcome of patients who opted for close surveillance with or without adjuvant chemoradiotherapy rather than radical surgery after local excision (LE) of early rectal cancer.<h4>Method</h4>The Royal Marsden Hospital Rectal Cancer database was used to identify rectal cancer patients treated by primary LE from 2006 to 2015. All patients were entered in an intensive surveillance programme.<h4>Results</h4>Twenty-eight of 34 analysed patients had a high or very high risk of residual disease predicted by adverse histopathological features for which the recommendation had been radical surgery. Eighteen (52%) of the 34 had received radiotherapy following LE. Three-year disease-free survival for the 34 patients was 85% (95% CI 78.8%-91.2%) and overall survival was 100%. Twenty-two of 24 patients with a low tumour which would have required total rectal excision have so far avoided radical surgery and remain disease free at a median follow-up of 3.2 years.<h4>Conclusion</h4>The findings suggest that with modern MRI and clinical surveillance radical surgery can be avoided in patients following initial LE of a histopathologically defined high risk early rectal cancer. These findings are comparable with those obtained after major radical resection and warrant further prospective investigation as a treatment arm in larger prospective trials.en_US
dc.formatPrinten_US
dc.format.extent139 - 147en_US
dc.languageengen_US
dc.language.isoengen_US
dc.rights.urihttp://www.rioxx.net/licenses/all-rights-reserveden_US
dc.subjectRectumen_US
dc.subjectHumansen_US
dc.subjectAdenocarcinomaen_US
dc.subjectRectal Neoplasmsen_US
dc.subjectMagnetic Resonance Imagingen_US
dc.subjectNeoplasm Stagingen_US
dc.subjectDisease-Free Survivalen_US
dc.subjectDigestive System Surgical Proceduresen_US
dc.subjectAdulten_US
dc.subjectAgeden_US
dc.subjectAged, 80 and overen_US
dc.subjectMiddle Ageden_US
dc.subjectFemaleen_US
dc.subjectMaleen_US
dc.subjectChemoradiotherapy, Adjuvanten_US
dc.subjectTransanal Endoscopic Microsurgeryen_US
dc.titleThe results of local excision with or without postoperative adjuvant chemoradiotherapy for early rectal cancer among patients choosing to avoid radical surgery.en_US
dc.typeJournal Article
dcterms.dateAccepted2016-04-17en_US
rioxxterms.versionofrecord10.1111/codi.13477en_US
rioxxterms.licenseref.startdate2017-02en_US
rioxxterms.typeJournal Article/Reviewen_US
dc.relation.isPartOfColorectal disease : the official journal of the Association of Coloproctology of Great Britain and Irelanden_US
pubs.issue2en_US
pubs.notesNot knownen_US
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies/Medicine (RMH Smith Cunningham)
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies/Medicine (RMH Smith Cunningham)/Medicine (RMH Smith Cunningham) (hon.)
pubs.organisational-group/ICR/Primary Group/Royal Marsden Clinical Units
pubs.publication-statusPublisheden_US
pubs.volume19en_US
pubs.embargo.termsNot knownen_US
icr.researchteamMedicine (RMH Smith Cunningham)en_US
dc.contributor.icrauthorCunningham, Daviden_US
dc.contributor.icrauthorMarsden,en_US


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