Browsing Structural Biology by author "Pettinger, Jonathan"

Now showing items 1-1 of 1

    • An Irreversible Inhibitor of HSP72 that Unexpectedly Targets Lysine-56. 

      Pettinger, J; Le Bihan, Y-V; Widya, M; van Montfort, RLM; Jones, K; et al. (WILEY-V C H VERLAG GMBH, 2017-03-20)
      The stress-inducible molecular chaperone, HSP72, is an important therapeutic target in oncology, but inhibiting this protein with small molecules has proven particularly challenging. Validating HSP72 inhibitors in cells ...