Browsing Structural Biology by author "Leonidou, Andri"
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SF3B1 mutations constitute a novel therapeutic target in breast cancer.
Maguire, SL; Leonidou, A; Wai, P; Marchiò, C; Ng, CK; et al. (WILEY, 2015-03-01)Mutations in genes encoding proteins involved in RNA splicing have been found to occur at relatively high frequencies in several tumour types including myelodysplastic syndromes, chronic lymphocytic leukaemia, uveal melanoma, ... -
Utilizing Functional Genomics Screening to Identify Potentially Novel Drug Targets in Cancer Cell Spheroid Cultures.
Morrison, E; Wai, P; Leonidou, A; Bland, P; Khalique, S; et al. (JOURNAL OF VISUALIZED EXPERIMENTS, 2016-12-26)The identification of functional driver events in cancer is central to furthering our understanding of cancer biology and indispensable for the discovery of the next generation of novel drug targets. It is becoming apparent ...