Browsing Structural Biology by author "Greber, Basil"
Now showing items 1-6 of 6
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Architecture of the chromatin remodeler RSC and insights into its nucleosome engagement.
Patel, AB; Moore, CM; Greber, BJ; Luo, J; Zukin, SA; et al. (ELIFE SCIENCES PUBLICATIONS LTD, 2019-12-30)Eukaryotic DNA is packaged into nucleosome arrays, which are repositioned by chromatin remodeling complexes to control DNA accessibility. The Saccharomyces cerevisiae RSC (Remodeling the Structure of Chromatin) complex, a ... -
Heterologous Assembly of Pleomorphic Bacterial Microcompartment Shell Architectures Spanning the Nano- to Microscale.
Ferlez, BH; Kirst, H; Greber, BJ; Nogales, E; Sutter, M; et al. (WILEY-V C H VERLAG GMBH, 2023-03-18)Many bacteria use protein-based organelles known as bacterial microcompartments (BMCs) to organize and sequester sequential enzymatic reactions. Regardless of their specialized metabolic function, all BMCs are delimited ... -
High-resolution cryo-EM of a small protein complex: The structure of the human CDK-activating kinase.
Greber, BJ (CELL PRESS, 2024-03-25)The human CDK-activating kinase (CAK) is a multifunctional protein complex and key regulator of cell growth and division. Because of its critical functions in regulating the cell cycle and transcription initiation, it is ... -
High-resolution cryo-EM of the human CDK-activating kinase for structure-based drug design
Cushing, VI; Koh, AF; Feng, J; Jurgaityte, K; Bondke, A; et al. (NATURE PORTFOLIO, 2024-03-13) -
Structural and quantum chemical basis for OCP-mediated quenching of phycobilisomes.
Sauer, PV; Cupellini, L; Sutter, M; Bondanza, M; Domínguez Martin, MA; et al. (AMER ASSOC ADVANCEMENT SCIENCE, 2024-04-05)Cyanobacteria use large antenna complexes called phycobilisomes (PBSs) for light harvesting. However, intense light triggers non-photochemical quenching, where the orange carotenoid protein (OCP) binds to PBS, dissipating ... -
Structural transitions in the GTP cap visualized by cryo-electron microscopy of catalytically inactive microtubules.
LaFrance, BJ; Roostalu, J; Henkin, G; Greber, BJ; Zhang, R; et al. (NATL ACAD SCIENCES, 2022-01-11)Microtubules (MTs) are polymers of αβ-tubulin heterodimers that stochastically switch between growth and shrinkage phases. This dynamic instability is critically important for MT function. It is believed that GTP hydrolysis ...