Now showing items 1-2 of 2
Demonstrating In-Cell Target Engagement Using a Pirin Protein Degradation Probe (CCT367766).
Demonstrating intracellular protein target engagement is an essential step in the development and progression of new chemical probes and potential small molecule therapeutics. However, this can be particularly challenging ...
Privileged Structures and Polypharmacology within and between Protein Families.
Polypharmacology is often a key contributor to the efficacy of a drug, but is also a potential risk. We investigated two hits discovered via a cell-based phenotypic screen, the CDK9 inhibitor CCT250006 (<b>1</b>) and the ...