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dc.contributor.authorFox, L
dc.contributor.authorToms, C
dc.contributor.authorKernaghan, S
dc.contributor.authorSnowdon, C
dc.contributor.authorBliss, JM
dc.date.accessioned2017-11-20T11:23:53Z
dc.date.issued2017-09-26
dc.identifier.citationTrials, 2017, 18 (1), pp. 440 - ?
dc.identifier.issn1745-6215
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/910
dc.identifier.eissn1745-6215
dc.identifier.doi10.1186/s13063-017-2176-0
dc.description.abstractBackground Academic clinical trials play a fundamental role in the development of new treatments, the repurposing of existing treatments and in addressing areas of unmet clinical need. With cancer treatments increasingly targeted at molecular subtypes, and with priority placed on developing new treatments for rare tumour types, the need for international trial participation to access sufficient patient numbers for successful trial conduct is growing. However, lack of harmonisation of international legal, ethical and financial systems can make this challenging and the cost and effort of conducting trials internationally can be considered prohibitive, particularly where the sample size is comparatively small.Methods The Institute of Cancer Research - Clinical Trials and Statistics Unit (ICR-CTSU) is a UK-based academic clinical trials unit that specialises in the design, conduct and analysis of clinical trials of cancer treatments with an expanding portfolio of trials in molecular subtypes of breast and urological cancers and in other rare cancer types. Implementing appropriate mechanisms to enable international participation has therefore been imperative. In this article, we explain how we have approached the challenges involved and describe examples of successful international trial conduct, achieved through robust collaborations with academic and industry partners.Conclusion Conducting academic trials internationally is challenging but can and should be achieved through appropriate governance mechanisms and strong collaborations.
dc.formatElectronic
dc.format.extent440 - ?
dc.languageeng
dc.language.isoeng
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.subjectHumans
dc.subjectNeoplasms
dc.subjectAntineoplastic Agents
dc.subjectTreatment Outcome
dc.subjectResearch Design
dc.subjectInternational Cooperation
dc.subjectDrug Costs
dc.subjectPolicy Making
dc.subjectClinical Trials as Topic
dc.subjectResearch Support as Topic
dc.subjectMulticenter Studies as Topic
dc.subjectPublic-Private Sector Partnerships
dc.titleConducting non-commercial international clinical trials: the ICR-CTSU experience.
dc.typeJournal Article
dcterms.dateAccepted2017-09-11
rioxxterms.versionofrecord10.1186/s13063-017-2176-0
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0
rioxxterms.licenseref.startdate2017-09-26
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfTrials
pubs.issue1
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies/Clinical Trials & Statistics Unit
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies/Clinical Trials & Statistics Unit
pubs.publication-statusPublished
pubs.volume18
pubs.embargo.termsNot known
icr.researchteamClinical Trials & Statistics Uniten_US
dc.contributor.icrauthorFox, Lisaen
dc.contributor.icrauthorKernaghan, Sarahen
dc.contributor.icrauthorBliss, Judithen
dc.contributor.icrauthorSnowdon, Claireen


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