Now showing items 1-4 of 4

    • The Heterocellular Emergence of Colorectal Cancer. 

      Tape, CJ (2017-02)
      Tissues contain multiple different cell types and can be considered to be heterocellular systems. Signaling between different cells allows tissues to achieve phenotypes that no cell type can achieve in isolation. Such ...
    • Oncogenic KRAS Regulates Tumor Cell Signaling via Stromal Reciprocation. 

      Tape, CJ; Ling, S; Dimitriadi, M; McMahon, KM; Worboys, JD; Leong, HS; Norrie, IC; Miller, CJ; Poulogiannis, G; Lauffenburger, DA; Jørgensen, C (2016-05)
      Oncogenic mutations regulate signaling within both tumor cells and adjacent stromal cells. Here, we show that oncogenic KRAS (KRAS(G12D)) also regulates tumor cell signaling via stromal cells. By combining cell-specific ...
    • Proteomics profiling of interactome dynamics by colocalisation analysis (COLA). 

      Mardakheh, FK; Sailem, HZ; Kümper, S; Tape, CJ; McCully, RR; Paul, A; Anjomani-Virmouni, S; Jørgensen, C; Poulogiannis, G; Marshall, CJ; Bakal, C (2016-12-20)
      Localisation and protein function are intimately linked in eukaryotes, as proteins are localised to specific compartments where they come into proximity of other functionally relevant proteins. Significant co-localisation ...
    • Reproducible automated phosphopeptide enrichment using magnetic TiO2 and Ti-IMAC. 

      Tape, CJ; Worboys, JD; Sinclair, J; Gourlay, R; Vogt, J; McMahon, KM; Trost, M; Lauffenburger, DA; Lamont, DJ; Jørgensen, C (2014-10-02)
      Reproducible, comprehensive phosphopeptide enrichment is essential for studying phosphorylation-regulated processes. Here, we describe the application of hyper-porous magnetic TiO2 and Ti-IMAC microspheres for uniform ...