The Heterocellular Emergence of Colorectal Cancer.
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Date
2017-02ICR Author
Author
Tape, CJ
Type
Journal Article
Metadata
Show full item recordAbstract
Tissues contain multiple different cell types and can be considered to be heterocellular systems. Signaling between different cells allows tissues to achieve phenotypes that no cell type can achieve in isolation. Such emergent tissue-level phenotypes can be said to 'supervene upon' heterocellular signaling. It is proposed here that cancer is also an emergent phenotype that supervenes upon heterocellular signaling. Using colorectal cancer (CRC) as an example, I review how heterotypic cells differentially communicate to support emergent malignancy. Studying tumors as integrated heterocellular systems - rather than as solitary expansions of mutated cells - may reveal novel ways to treat cancer.
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Subject
Clone Cells
Humans
Colorectal Neoplasms
Cell Communication
Signal Transduction
Cell Lineage
Genetic Heterogeneity
Research team
Oncogene
Language
eng
License start date
2017-02
Citation
Trends in cancer, 2017, 3 (2), pp. 79 - 88