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dc.contributor.authorTape, CJen_US
dc.coverage.spatialUnited Statesen_US
dc.date.accessioned2017-02-01T12:31:09Z
dc.date.issued2017-02en_US
dc.identifierhttps://www.ncbi.nlm.nih.gov/pubmed/28239669en_US
dc.identifierS2405-8033(16)30208-4en_US
dc.identifier.citationTrends Cancer, 2017, 3 (2), pp. 79 - 88en_US
dc.identifier.issn2405-8033en_US
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/403
dc.identifier.doi10.1016/j.trecan.2016.12.004en_US
dc.description.abstractTissues contain multiple different cell types and can be considered to be heterocellular systems. Signaling between different cells allows tissues to achieve phenotypes that no cell type can achieve in isolation. Such emergent tissue-level phenotypes can be said to 'supervene upon' heterocellular signaling. It is proposed here that cancer is also an emergent phenotype that supervenes upon heterocellular signaling. Using colorectal cancer (CRC) as an example, I review how heterotypic cells differentially communicate to support emergent malignancy. Studying tumors as integrated heterocellular systems - rather than as solitary expansions of mutated cells - may reveal novel ways to treat cancer.en_US
dc.format.extent79 - 88en_US
dc.languageengen_US
dc.language.isoengen_US
dc.subjectCell Communicationen_US
dc.subjectCell Lineageen_US
dc.subjectClone Cellsen_US
dc.subjectColorectal Neoplasmsen_US
dc.subjectGenetic Heterogeneityen_US
dc.subjectHumansen_US
dc.subjectSignal Transductionen_US
dc.titleThe Heterocellular Emergence of Colorectal Cancer.en_US
dc.typeJournal Article
rioxxterms.versionofrecord10.1016/j.trecan.2016.12.004en_US
rioxxterms.licenseref.startdate2017-02en_US
rioxxterms.typeJournal Article/Reviewen_US
dc.relation.isPartOfTrends Canceren_US
pubs.issue2en_US
pubs.notesNot knownen_US
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Cancer Biology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Cancer Biology/Oncogene
pubs.publication-statusPublisheden_US
pubs.volume3en_US
pubs.embargo.termsNot knownen_US
icr.researchteamOncogeneen_US
dc.contributor.icrauthorTape, Christopheren_US


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