Browsing by author "Da Pieve, Chiara"
Now showing items 1-13 of 13
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A general [<SUP>18</SUP>F]AlF radiochemistry procedure on two automated synthesis platforms
Allott, L; Da Pieve, C; Turton, DR; Smith, G (ROYAL SOC CHEMISTRY, 2017-02-01)<p>The first general [<sup>18</sup>F]AIF automated radiolabelling procedure developed on the GE Tracerlab FX FN (Left) and Trasis AllInOne (Right) platforms.</p> -
Affibody-Based PET Imaging to Guide EGFR-Targeted Cancer Therapy in Head and Neck Squamous Cell Cancer Models.
Burley, TA; Da Pieve, C; Martins, CD; Ciobota, DM; Allott, L; et al. (SOC NUCLEAR MEDICINE INC, 2019-03-01)In head and neck squamous cell cancer, the human epidermal growth factor receptor 1 (EGFR) is the dominant signaling molecule among all members of the family. So far, cetuximab is the only approved anti-EGFR monoclonal ... -
Efficient [(18)F]AlF Radiolabeling of ZHER3:8698 Affibody Molecule for Imaging of HER3 Positive Tumors.
Da Pieve, C; Allott, L; Martins, CD; Vardon, A; Ciobota, DM; et al. (AMER CHEMICAL SOC, 2016-08-17)The human epidermal growth factor receptor 3 (HER3) is overexpressed in several cancers, being linked to a more resistant phenotype and hence leading to poor patient prognosis. Imaging HER3 is challenging owing to the ... -
Evaluation of DFO-HOPO as an octadentate chelator for zirconium-89.
Allott, L; Da Pieve, C; Meyers, J; Spinks, T; Ciobota, DM; et al. (ROYAL SOC CHEMISTRY, 2017-07-27)The future of 89Zr-based immuno-PET is reliant upon the development of new chelators with improved stability compared to the currently used deferoxamine (DFO). Herein, we report the evaluation of the octadentate molecule ... -
HER3-Mediated Resistance to Hsp90 Inhibition Detected in Breast Cancer Xenografts by Affibody-Based PET Imaging.
Martins, CD; Da Pieve, C; Burley, TA; Smith, R; Ciobota, DM; et al. (AMER ASSOC CANCER RESEARCH, 2018-04-15)Purpose: Recent studies have highlighted a role of HER3 in HER2-driven cancers (e.g., breast cancer), implicating the upregulation of the receptor in resistance to HER-targeted therapies and Hsp90 inhibitors (e.g., AUY922). ... -
Immuno-PET Imaging of Tumour PD-L1 Expression in Glioblastoma.
Sharma, G; Braga, MC; Da Pieve, C; Szopa, W; Starzetz, T; et al. (MDPI, 2023-06-09)There is no established method to assess the PD-L1 expression in brain tumours. Therefore, we investigated the suitability of affibody molecule (ZPD-L1) radiolabelled with F-18 (Al18F) and Ga-68 to measure the expression ... -
Immunomodulatory activity of IR700-labelled affibody targeting HER2.
Mączyńska, J; Da Pieve, C; Burley, TA; Raes, F; Shah, A; et al. (SPRINGERNATURE, 2020-10-20)There is an urgent need to develop therapeutic approaches that can increase the response rate to immuno-oncology agents. Photoimmunotherapy has recently been shown to generate anti-tumour immunological responses by releasing ... -
New Fully Automated Preparation of High Apparent Molar Activity 68Ga-FAPI-46 on a Trasis AiO Platform.
Da Pieve, C; Costa Braga, M; Turton, DR; Valla, FA; Cakmak, P; et al. (MDPI, 2022-01-20)A large number of applications for fibroblast activation protein inhibitors (FAPI)-based PET agents have been evaluated in conditions ranging from cancer to non-malignant diseases such as myocardial infarction. In particular, ... -
Pre-clinical quantitative imaging and mouse-specific dosimetry for 111In-labelled radiotracers.
Denis-Bacelar, AM; Cronin, SE; Da Pieve, C; Paul, RL; Eccles, SA; et al. (SPRINGER HEIDELBERG, 2016-11-25)BACKGROUND: Accurate quantification in molecular imaging is essential to improve the assessment of novel drugs and compare the radiobiological effects of therapeutic agents prior to in-human studies. The aim of this study ... -
Radiosynthesis of the anticancer nucleoside analogue Trifluridine using an automated 18F-trifluoromethylation procedure.
King, A; Doepner, A; Turton, D; Ciobota, DM; Da Pieve, C; et al. (ROYAL SOC CHEMISTRY, 2018-04-25)Trifluoromethyl groups are widespread in medicinal chemistry, yet there are limited 18F-radiochemistry techniques available for the production of the complementary PET agents. Herein, we report the first radiosynthesis of ... -
Shortwave Infrared Imaging Enables High-Contrast Fluorescence-Guided Surgery in Neuroblastoma.
Privitera, L; Waterhouse, DJ; Preziosi, A; Paraboschi, I; Ogunlade, O; et al. (AMER ASSOC CANCER RESEARCH, 2023-06-15)UNLABELLED: Fluorescence-guided surgery is set to play a pivotal role in the intraoperative management of pediatric tumors. Shortwave infrared imaging (SWIR) has advantages over conventional near-infrared I (NIR-I) imaging ... -
Thiol-Reactive PODS-Bearing Bifunctional Chelators for the Development of EGFR-Targeting [18F]AlF-Affibody Conjugates.
Da Pieve, C; Makarem, A; Turnock, S; Maczynska, J; Smith, G; et al. (MDPI, 2020-03-29)Site-selective bioconjugation of cysteine-containing peptides and proteins is currently achieved via a maleimide-thiol reaction (Michael addition). When maleimide-functionalized chelators are used and the resulting ... -
Triggering anti-GBM immune response with EGFR-mediated photoimmunotherapy.
Mączyńska, J; Raes, F; Da Pieve, C; Turnock, S; Boult, JKR; et al. (BMC, 2022-01-21)BACKGROUND: Surgical resection followed by chemo-radiation postpones glioblastoma (GBM) progression and extends patient survival, but these tumours eventually recur. Multimodal treatment plans combining intraoperative ...