Evaluation of DFO-HOPO as an octadentate chelator for zirconium-89.

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Date
2017-07-27
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Author
Allott, L
Da Pieve, C
Meyers, J
Spinks, T
Ciobota, DM
Type
Journal Article
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Abstract
The future of 89Zr-based immuno-PET is reliant upon the development of new chelators with improved stability compared to the currently used deferoxamine (DFO). Herein, we report the evaluation of the octadentate molecule DFO-HOPO (3) as a suitable chelator for 89Zr and a more stable alternative to DFO. The molecule showed good potential for the future development of a DFO-HOPO-based bifunctional chelator (BFC) for the radiolabelling of biomolecules with 89Zr. This work broadens the selection of available chelators for 89Zr in search of improved successors to DFO for clinical 89Zr-immuno-PET.
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https://repository.icr.ac.uk/handle/internal/736
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Medicinal Chemistry 1
PET Radiochemistry
Preclinical Molecular Imaging
Language
eng
Date accepted
2017-07-07
License start date
2017-07
Citation
Chemical communications (Cambridge, England), 2017, 53 (61), pp. 8529 - 8532
Publisher
ROYAL SOC CHEMISTRY
https://creativecommons.org/licenses/by/4.0
Except where otherwise noted, this item's license is described as https://creativecommons.org/licenses/by/4.0