Evaluation of DFO-HOPO as an octadentate chelator for zirconium-89.
Da Pieve, C
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The future of <sup>89</sup>Zr-based immuno-PET is reliant upon the development of new chelators with improved stability compared to the currently used deferoxamine (DFO). Herein, we report the evaluation of the octadentate molecule DFO-HOPO (3) as a suitable chelator for <sup>89</sup>Zr and a more stable alternative to DFO. The molecule showed good potential for the future development of a DFO-HOPO-based bifunctional chelator (BFC) for the radiolabelling of biomolecules with <sup>89</sup>Zr. This work broadens the selection of available chelators for <sup>89</sup>Zr in search of improved successors to DFO for clinical <sup>89</sup>Zr-immuno-PET.
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Medicinal Chemistry 1
Preclinical Molecular Imaging
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Chemical communications (Cambridge, England), 2017, 53 (61), pp. 8529 - 8532