Browsing by author "Fletcher, Olivia"
Now showing items 1-20 of 42
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A transcriptome-wide association study of 229,000 women identifies new candidate susceptibility genes for breast cancer.
Wu, L; Shi, W; Long, J; Guo, X; Michailidou, K; et al. (NATURE PUBLISHING GROUP, 2018-07-01)The breast cancer risk variants identified in genome-wide association studies explain only a small fraction of the familial relative risk, and the genes responsible for these associations remain largely unknown. To identify ... -
Age- and Tumor Subtype-Specific Breast Cancer Risk Estimates for CHEK2*1100delC Carriers.
Schmidt, MK; Hogervorst, F; van Hien, R; Cornelissen, S; Broeks, A; et al. (AMER SOC CLINICAL ONCOLOGY, 2016-08-10)PURPOSE: CHEK2*1100delC is a well-established breast cancer risk variant that is most prevalent in European populations; however, there are limited data on risk of breast cancer by age and tumor subtype, which limits its ... -
Aggregation tests identify new gene associations with breast cancer in populations with diverse ancestry.
Mueller, SH; Lai, AG; Valkovskaya, M; Michailidou, K; Bolla, MK; et al. (BMC, 2023-01-26)BACKGROUND: Low-frequency variants play an important role in breast cancer (BC) susceptibility. Gene-based methods can increase power by combining multiple variants in the same gene and help identify target genes. METHODS: ... -
Association analysis identifies 65 new breast cancer risk loci.
Michailidou, K; Lindström, S; Dennis, J; Beesley, J; Hui, S; et al. (2017-11)Breast cancer risk is influenced by rare coding variants in susceptibility genes, such as BRCA1, and many common, mostly non-coding variants. However, much of the genetic contribution to breast cancer risk remains unknown. ... -
Association of genetic susceptibility variants for type 2 diabetes with breast cancer risk in women of European ancestry.
Zhao, Z; Wen, W; Michailidou, K; Bolla, MK; Wang, Q; et al. (SPRINGER, 2016-05-01)PURPOSE: Type 2 diabetes (T2D) has been reported to be associated with an elevated risk of breast cancer. It is unclear, however, whether this association is due to shared genetic factors. METHODS: We constructed a genetic ... -
Associations of obesity and circulating insulin and glucose with breast cancer risk: a Mendelian randomization analysis.
Shu, X; Wu, L; Khankari, NK; Shu, X-O; Wang, TJ; et al. (OXFORD UNIV PRESS, 2019-06-01)BACKGROUND: In addition to the established association between general obesity and breast cancer risk, central obesity and circulating fasting insulin and glucose have been linked to the development of this common malignancy. ... -
Candidate gene-environment interactions in breast cancer.
Fletcher, O; Dudbridge, F (BIOMED CENTRAL LTD, 2014-10-17)Gene-environment interactions have the potential to shed light on biological processes leading to disease, identify individuals for whom risk factors are most relevant, and improve the accuracy of epidemiological risk ... -
Capture Hi-C identifies putative target genes at 33 breast cancer risk loci.
Baxter, JS; Leavy, OC; Dryden, NH; Maguire, S; Johnson, N; et al. (NATURE PUBLISHING GROUP, 2018-03-12)Genome-wide association studies (GWAS) have identified approximately 100 breast cancer risk loci. Translating these findings into a greater understanding of the mechanisms that influence disease risk requires identification ... -
Capture Hi-C identifies the chromatin interactome of colorectal cancer risk loci.
Jäger, R; Migliorini, G; Henrion, M; Kandaswamy, R; Speedy, HE; et al. (NATURE PORTFOLIO, 2015-02-19)Multiple regulatory elements distant from their targets on the linear genome can influence the expression of a single gene through chromatin looping. Chromosome conformation capture implemented in Hi-C allows for genome-wide ... -
Common Susceptibility Loci for Male Breast Cancer.
Maguire, S; Perraki, E; Tomczyk, K; Jones, ME; Fletcher, O; et al. (OXFORD UNIV PRESS INC, 2021-04-06)BACKGROUND: The etiology of male breast cancer (MBC) is poorly understood. In particular, the extent to which the genetic basis of MBC differs from female breast cancer (FBC) is unknown. A previous genome-wide association ... -
Cross-Cancer Genome-Wide Analysis of Lung, Ovary, Breast, Prostate, and Colorectal Cancer Reveals Novel Pleiotropic Associations.
Fehringer, G; Kraft, P; Pharoah, PD; Eeles, RA; Chatterjee, N; et al. (AMER ASSOC CANCER RESEARCH, 2016-09-01)Identifying genetic variants with pleiotropic associations can uncover common pathways influencing multiple cancers. We took a two-stage approach to conduct genome-wide association studies for lung, ovary, breast, prostate, ... -
CYP3A7*1C allele is associated with reduced levels of 2-hydroxylation pathway oestrogen metabolites.
Sood, D; Johnson, N; Jain, P; Siskos, AP; Bennett, M; et al. (NATURE PUBLISHING GROUP, 2017-01-31)BACKGROUND: Endogenous sex hormones are well-established risk factors for breast cancer; the contribution of specific oestrogen metabolites (EMs) and/or ratios of specific EMs is less clear. We have previously identified ... -
CYP3A7*1C allele: linking premenopausal oestrone and progesterone levels with risk of hormone receptor-positive breast cancers.
Johnson, N; Maguire, S; Morra, A; Kapoor, PM; Tomczyk, K; et al. (SPRINGERNATURE, 2021-02-16)BACKGROUND: Epidemiological studies provide strong evidence for a role of endogenous sex hormones in the aetiology of breast cancer. The aim of this analysis was to identify genetic variants that are associated with urinary ... -
DNA methylation of the long intergenic noncoding RNA 299 gene in triple-negative breast cancer: results from a prospective study.
Manoochehri, M; Jones, M; Tomczyk, K; Fletcher, O; Schoemaker, MJ; et al. (NATURE PUBLISHING GROUP, 2020-07-16)Triple-negative breast cancer (TNBC) is an aggressive breast cancer subtype associated with a high rate of recurrence and poor prognosis. Recently we identified a hypermethylation in the long noncoding RNA 299 (LINC00299) ... -
Epigenome-wide association study for lifetime estrogen exposure identifies an epigenetic signature associated with breast cancer risk.
Johansson, A; Palli, D; Masala, G; Grioni, S; Agnoli, C; et al. (BMC, 2019-04-30)BACKGROUND: It is well established that estrogens and other hormonal factors influence breast cancer susceptibility. We hypothesized that a woman's total lifetime estrogen exposure accumulates changes in DNA methylation, ... -
Evaluation of European-based polygenic risk score for breast cancer in Ashkenazi Jewish women in Israel.
Levi, H; Carmi, S; Rosset, S; Yerushalmi, R; Zick, A; et al. (BMJ PUBLISHING GROUP, 2023-11-27)BACKGROUND: Polygenic risk score (PRS), calculated based on genome-wide association studies (GWASs), can improve breast cancer (BC) risk assessment. To date, most BC GWASs have been performed in individuals of European ... -
Evaluation of the Association of Polymorphisms With Palbociclib-Induced Neutropenia: Pharmacogenetic Analysis of PALOMA-2/-3.
Iwata, H; Umeyama, Y; Liu, Y; Zhang, Z; Schnell, P; et al. (WILEY, 2021-07-01)BACKGROUND: The most frequently reported treatment-related adverse event in clinical trials with the cyclin-dependent kinase 4/6 (CDK4/6) inhibitor palbociclib is neutropenia. Allelic variants in ABCB1 and ERCC1 might be ... -
Evidence that the 5p12 Variant rs10941679 Confers Susceptibility to Estrogen-Receptor-Positive Breast Cancer through FGF10 and MRPS30 Regulation.
Ghoussaini, M; French, JD; Michailidou, K; Nord, S; Beesley, J; et al. (CELL PRESS, 2016-10-06)Genome-wide association studies (GWASs) have revealed increased breast cancer risk associated with multiple genetic variants at 5p12. Here, we report the fine mapping of this locus using data from 104,660 subjects from 50 ... -
Fine scale mapping of the 17q22 breast cancer locus using dense SNPs, genotyped within the Collaborative Oncological Gene-Environment Study (COGs).
Darabi, H; Beesley, J; Droit, A; Kar, S; Nord, S; et al. (NATURE PORTFOLIO, 2016-09-07)Genome-wide association studies have found SNPs at 17q22 to be associated with breast cancer risk. To identify potential causal variants related to breast cancer risk, we performed a high resolution fine-mapping analysis ... -
Fine-mapping of 150 breast cancer risk regions identifies 191 likely target genes.
Fachal, L; Aschard, H; Beesley, J; Barnes, DR; Allen, J; et al. (NATURE PORTFOLIO, 2020-01-07)Genome-wide association studies have identified breast cancer risk variants in over 150 genomic regions, but the mechanisms underlying risk remain largely unknown. These regions were explored by combining association ...