Fine scale mapping of the 17q22 breast cancer locus using dense SNPs, genotyped within the Collaborative Oncological Gene-Environment Study (COGs).
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Date
2016-09-07Author
Darabi, H
Beesley, J
Droit, A
Kar, S
Nord, S
Moradi Marjaneh, M
Soucy, P
Michailidou, K
Ghoussaini, M
Fues Wahl, H
Bolla, MK
Wang, Q
Dennis, J
Alonso, MR
Andrulis, IL
Anton-Culver, H
Arndt, V
Beckmann, MW
Benitez, J
Bogdanova, NV
Bojesen, SE
Brauch, H
Brenner, H
Broeks, A
Brüning, T
Burwinkel, B
Chang-Claude, J
Choi, J-Y
Conroy, DM
Couch, FJ
Cox, A
Cross, SS
Czene, K
Devilee, P
Dörk, T
Easton, DF
Fasching, PA
Figueroa, J
Fletcher, O
Flyger, H
Galle, E
García-Closas, M
Giles, GG
Goldberg, MS
González-Neira, A
Guénel, P
Haiman, CA
Hallberg, E
Hamann, U
Hartman, M
Hollestelle, A
Hopper, JL
Ito, H
Jakubowska, A
Johnson, N
Kang, D
Khan, S
Kosma, V-M
Kriege, M
Kristensen, V
Lambrechts, D
Le Marchand, L
Lee, SC
Lindblom, A
Lophatananon, A
Lubinski, J
Mannermaa, A
Manoukian, S
Margolin, S
Matsuo, K
Mayes, R
McKay, J
Meindl, A
Milne, RL
Muir, K
Neuhausen, SL
Nevanlinna, H
Olswold, C
Orr, N
Peterlongo, P
Pita, G
Pylkäs, K
Rudolph, A
Sangrajrang, S
Sawyer, EJ
Schmidt, MK
Schmutzler, RK
Seynaeve, C
Shah, M
Shen, C-Y
Shu, X-O
Southey, MC
Stram, DO
Surowy, H
Swerdlow, A
Teo, SH
Tessier, DC
Tomlinson, I
Torres, D
Truong, T
Vachon, CM
Vincent, D
Winqvist, R
Wu, AH
Wu, P-E
Yip, CH
Zheng, W
Pharoah, PDP
Hall, P
Edwards, SL
Simard, J
French, JD
Chenevix-Trench, G
Dunning, AM
Type
Journal Article
Metadata
Show full item recordAbstract
Genome-wide association studies have found SNPs at 17q22 to be associated with breast cancer risk. To identify potential causal variants related to breast cancer risk, we performed a high resolution fine-mapping analysis that involved genotyping 517 SNPs using a custom Illumina iSelect array (iCOGS) followed by imputation of genotypes for 3,134 SNPs in more than 89,000 participants of European ancestry from the Breast Cancer Association Consortium (BCAC). We identified 28 highly correlated common variants, in a 53 Kb region spanning two introns of the STXBP4 gene, that are strong candidates for driving breast cancer risk (lead SNP rs2787486 (OR = 0.92; CI 0.90-0.94; P = 8.96 × 10(-15))) and are correlated with two previously reported risk-associated variants at this locus, SNPs rs6504950 (OR = 0.94, P = 2.04 × 10(-09), r(2) = 0.73 with lead SNP) and rs1156287 (OR = 0.93, P = 3.41 × 10(-11), r(2) = 0.83 with lead SNP). Analyses indicate only one causal SNP in the region and several enhancer elements targeting STXBP4 are located within the 53 kb association signal. Expression studies in breast tumor tissues found SNP rs2787486 to be associated with increased STXBP4 expression, suggesting this may be a target gene of this locus.
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http://www.ncbi.nlm.nih.gov/pubmed/27600471Collections
Subject
Chromosomes, Human, Pair 17
Humans
Breast Neoplasms
Genetic Predisposition to Disease
Vesicular Transport Proteins
Chromosome Mapping
Genotype
Polymorphism, Single Nucleotide
Quantitative Trait Loci
European Continental Ancestry Group
Female
Genome-Wide Association Study
Research team
Complex Trait Genetics
Functional Genetic Epidemiology
Aetiological Epidemiology
Language
eng
Date accepted
2016-08-03
License start date
2016-09-07
Citation
Scientific reports, 2016, 6 pp. 32512 - ?
Publisher
NATURE PORTFOLIO