Now showing items 1459-1478 of 3103

    • Integrated Molecular Meta-Analysis of 1,000 Pediatric High-Grade and Diffuse Intrinsic Pontine Glioma. 

      Mackay, A; Burford, A; Carvalho, D; Izquierdo, E; Fazal-Salom, J; Taylor, KR; Bjerke, L; Clarke, M; Vinci, M; Nandhabalan, M; Temelso, S; Popov, S; Molinari, V; Raman, P; Waanders, AJ; Han, HJ; Gupta, S; Marshall, L; Zacharoulis, S; Vaidya, S; Mandeville, HC; Bridges, LR; Martin, AJ; Al-Sarraj, S; Chandler, C; Ng, H-K; Li, X; Mu, K; Trabelsi, S; Brahim, DH-B; Kisljakov, AN; Konovalov, DM; Moore, AS; Carcaboso, AM; Sunol, M; de Torres, C; Cruz, O; Mora, J; Shats, LI; Stavale, JN; Bidinotto, LT; Reis, RM; Entz-Werle, N; Farrell, M; Cryan, J; Crimmins, D; Caird, J; Pears, J; Monje, M; Debily, M-A; Castel, D; Grill, J; Hawkins, C; Nikbakht, H; Jabado, N; Baker, SJ; Pfister, SM; Jones, DTW; Fouladi, M; von Bueren, AO; Baudis, M; Resnick, A; Jones, C (2017-10-09)
      We collated data from 157 unpublished cases of pediatric high-grade glioma and diffuse intrinsic pontine glioma and 20 publicly available datasets in an integrated analysis of >1,000 cases. We identified co-segregating ...
    • Integrated Molecular Meta-Analysis of 1,000 Pediatric High-Grade and Diffuse Intrinsic Pontine Glioma. 

      Mackay, A; Burford, A; Carvalho, D; Izquierdo, E; Fazal-Salom, J; Taylor, KR; Bjerke, L; Clarke, M; Vinci, M; Nandhabalan, M; Temelso, S; Popov, S; Molinari, V; Raman, P; Waanders, AJ; Han, HJ; Gupta, S; Marshall, L; Zacharoulis, S; Vaidya, S; Mandeville, HC; Bridges, LR; Martin, AJ; Al-Sarraj, S; Chandler, C; Ng, H-K; Li, X; Mu, K; Trabelsi, S; Brahim, DH-B; Kisljakov, AN; Konovalov, DM; Moore, AS; Carcaboso, AM; Sunol, M; de Torres, C; Cruz, O; Mora, J; Shats, LI; Stavale, JN; Bidinotto, LT; Reis, RM; Entz-Werle, N; Farrell, M; Cryan, J; Crimmins, D; Caird, J; Pears, J; Monje, M; Debily, M-A; Castel, D; Grill, J; Hawkins, C; Nikbakht, H; Jabado, N; Baker, SJ; Pfister, SM; Jones, DTW; Fouladi, M; von Bueren, AO; Baudis, M; Resnick, A; Jones, C (2017-10-09)
      We collated data from 157 unpublished cases of pediatric high-grade glioma and diffuse intrinsic pontine glioma and 20 publicly available datasets in an integrated analysis of >1,000 cases. We identified co-segregating ...
    • Integrated Molecular Meta-Analysis of 1,000 Pediatric High-Grade and Diffuse Intrinsic Pontine Glioma. 

      Mackay, A; Burford, A; Carvalho, D; Izquierdo, E; Fazal-Salom, J; Taylor, KR; Bjerke, L; Clarke, M; Vinci, M; Nandhabalan, M; Temelso, S; Popov, S; Molinari, V; Raman, P; Waanders, AJ; Han, HJ; Gupta, S; Marshall, L; Zacharoulis, S; Vaidya, S; Mandeville, HC; Bridges, LR; Martin, AJ; Al-Sarraj, S; Chandler, C; Ng, H-K; Li, X; Mu, K; Trabelsi, S; Brahim, DH-B; Kisljakov, AN; Konovalov, DM; Moore, AS; Carcaboso, AM; Sunol, M; de Torres, C; Cruz, O; Mora, J; Shats, LI; Stavale, JN; Bidinotto, LT; Reis, RM; Entz-Werle, N; Farrell, M; Cryan, J; Crimmins, D; Caird, J; Pears, J; Monje, M; Debily, M-A; Castel, D; Grill, J; Hawkins, C; Nikbakht, H; Jabado, N; Baker, SJ; Pfister, SM; Jones, DTW; Fouladi, M; von Bueren, AO; Baudis, M; Resnick, A; Jones, C (2017-10-09)
      We collated data from 157 unpublished cases of pediatric high-grade glioma and diffuse intrinsic pontine glioma and 20 publicly available datasets in an integrated analysis of >1,000 cases. We identified co-segregating ...
    • Integrated multiomics approach identifies calcium and integrin-binding protein-2 as a novel gene for pulse wave velocity 

      Yuan, Wei (2016)
      Background: Carotid-femoral pulse wave velocity (PWV) is an important measure of arterial stiffness, which is an independent predictor of cardiovascular morbidity and mortality. In this study, we used an integrated genetic, ...
    • The integration of BRCA testing into oncology clinics. 

      Percival, N; George, A; Gyertson, J; Hamill, M; Fernandes, A; Davies, E; Rahman, N; Banerjee, S (2016-06)
      The PARP inhibitor, Olaparib, is approved for women with BRCA-mutated ovarian cancer. Therefore there is an urgent need to test patients and obtain results in time to influence treatment. Models of BRCA testing, such as ...
    • Integration of Clinical Variables for the Prediction of Late Distant Recurrence in Patients With Estrogen Receptor-Positive Breast Cancer Treated With 5 Years of Endocrine Therapy: CTS5. 

      Dowsett, M; Sestak, I; Regan, MM; Dodson, A; Viale, G; Thürlimann, B; Colleoni, M; Cuzick, J (2018-07-01)
      Purpose Estimating risk of late distant recurrence (DR) is an important goal for managing women with hormone receptor-positive breast cancer after 5 years of endocrine treatment without recurrence. We developed and validated ...
    • The integration of docetaxel into first-line chemotherapy for ovarian cancer. 

      Kaye, SB (2001-01)
      Docetaxel is being explored as an alternative to paclitaxel in the treatment of ovarian cancer for several reasons: a) evidence of superiority in preclinical models; b) at least comparable activity in platinum-refractory ...
    • INTEND II randomized clinical trial of intraoperative duct endoscopy in pathological nipple discharge. 

      Gui, G; Agusti, A; Twelves, D; Tang, S; Kabir, M; Montgomery, C; Nerurkar, A; Osin, P; Isacke, C (2018-11)
      BACKGROUND: The majority of lesions resulting in pathological nipple discharge are benign. Conventional surgery is undirected and targeting the causative lesion by duct endoscopy may enable more accurate surgery with fewer ...
    • Intensity modulated radiotherapy in locally advanced thyroid cancer: Outcomes of a sequential phase I dose-escalation study. 

      Rooney, KP; Miah, AB; Bhide, SA; Guerrero-Urbano, MT; Sharabiani, MT; Newbold, KL; Grove, L; Harrington, KJ; Nutting, CM (2018-04)
      BACKGROUND AND PURPOSE: To determine the safety and tolerability of dose-escalation using modestly accelerated IMRT in high-risk locally advanced thyroid cancer requiring post-operative radiotherapy, and to report preliminary ...
    • Inter- and intra-tumoural heterogeneity in cancer-associated fibroblasts of human pancreatic ductal adenocarcinoma. 

      Neuzillet, C; Tijeras-Raballand, A; Ragulan, C; Cros, J; Patil, Y; Martinet, M; Erkan, M; Kleeff, J; Wilson, J; Apte, M; Tosolini, M; Wilson, AS; Delvecchio, FR; Bousquet, C; Paradis, V; Hammel, P; Sadanandam, A; Kocher, HM (2019-05)
      Cancer-associated fibroblasts (CAF) are orchestrators of the pancreatic ductal adenocarcinoma (PDAC) microenvironment. Stromal heterogeneity may explain differential pathophysiological roles of the stroma (pro- versus ...
    • Inter-individual differences in the ability of human milk-fat extracts to enhance the genotoxic potential of the procarcinogen benzo[a]pyrene in MCF-7 breast cells 

      Kalantzi, OI; Hewitt, R; Ford, KJ; Alcock, RE; Thomas, GO; Morris, JA; Hewer, A; Phillips, DH; Jones, KC; Martin, FL (AMER CHEMICAL SOC, 2004-07-01)
      Environmental factors are believed to play an important role in cancer aetiology. Whether environmental pollutants act in isolation or in combination within mixtures remains unclear. Four human milk-fat extracts (from ...
    • The inter-ring arrangement of the cytosolic chaperonin CCT 

      Martín-Benito, J; Grantham, J; Boskovic, J; Brackley, KI; Carrascosa, JL; Willison, KR; Valpuesta, JM (2007-03)
      The eukaryotic cytosolic chaperonin CCT (chaperonin containing TCP-1) is the most complex of all chaperonins—an oligomeric structure built from two identical rings, each composed of single copies of eight different subunits. ...
    • The interaction network of the chaperonin CCT 

      Dekker, C; Stirling, PC; McCormack, EA; Filmore, H; Paul, A; Brost, RL; Costanzo, M; Boone, C; Leroux, MR; Willison, KR (NATURE PUBLISHING GROUP, 2008-07-09)
      The eukaryotic cytosolic chaperonin containing TCP-1 (CCT) has an important function in maintaining cellular homoeostasis by assisting the folding of many proteins, including the cytoskeletal components actin and tubulin. ...
    • Interactions of GATA-2 with the promyelocytic leukemia zinc finger (PLZF) protein, its homologue FAZF, and the t(11;17)-generated PLZF-retinoic acid receptor alpha oncoprotein 

      Tsuzuki, S; Enver, T (2002-05-01)
      Transcription factor GATA-2 Is Implicated in the survival and growth of multipotential progenitors. Here we report that the promyelocytic leukemia zinc finger (PLZF) protein can Interact with GATA-2 and can modify Its ...
    • Interface dosimetry: measurements and Monte Carlo simulations of low-energy photon beams 

      Das, IJ; Kassaee, A; Verhaegen, F; Moskvin, VP (PERGAMON-ELSEVIER SCIENCE LTD, 2001-06)
      A comparison of measured and simulated dose perturbations at high-Z interfaces with Monte Carlo (MC) codes, EGS4, MCNP4B, and PENELOPE, having varied algorithms is presented. The measured dose perturbations strongly depend ...
    • Interfaces of Malignant and Immunologic Clonal Dynamics in Ovarian Cancer. 

      Zhang, AW; McPherson, A; Milne, K; Kroeger, DR; Hamilton, PT; Miranda, A; Funnell, T; Little, N; de Souza, CPE; Laan, S; LeDoux, S; Cochrane, DR; Lim, JLP; Yang, W; Roth, A; Smith, MA; Ho, J; Tse, K; Zeng, T; Shlafman, I; Mayo, MR; Moore, R; Failmezger, H; Heindl, A; Wang, YK; Bashashati, A; Grewal, DS; Brown, SD; Lai, D; Wan, ANC; Nielsen, CB; Huebner, C; Tessier-Cloutier, B; Anglesio, MS; Bouchard-Côté, A; Yuan, Y; Wasserman, WW; Gilks, CB; Karnezis, AN; Aparicio, S; McAlpine, JN; Huntsman, DG; Holt, RA; Nelson, BH; Shah, SP (2018-06-14)
      High-grade serous ovarian cancer (HGSC) exhibits extensive malignant clonal diversity with widespread but non-random patterns of disease dissemination. We investigated whether local immune microenvironment factors shape ...
    • Interferon alpha and zidovudine therapy in adult T-cell leukaemia lymphoma: response and outcome in 15 patients 

      Matutes, E; Taylor, GP; Cavenagh, J; Pagliuca, A; Bareford, D; Domingo, A; Hamblin, R; Kelsey, S; Mir, N; Reilly, JT (BLACKWELL SCIENCE LTD, 2001-06)
      Adult T-cell leukaemia lymphoma (ATLL) is an aggressive disease caused by the human T-lymphotropic virus 1 (HTLV-I) with a short survival, Responses to interferon alpha (IFN-alpha) and zidovudine (AZT) have been documented ...
    • An intergenic risk locus containing an enhancer deletion in 2q35 modulates breast cancer risk by deregulating IGFBP5 expression. 

      Wyszynski, A; Hong, CC; Lam, K; Michailidou, K; Lytle, C; Yao, S; Zhang, Y; Bolla, MK; Wang, Q; Dennis, J; Hopper, JL; Southey, MC; Schmidt, MK; Broeks, A; Muir, K; Lophatananon, A; Fasching, PA; Beckmann, MW; Peto, J; Dos-Santos-Silva, I; Sawyer, EJ; Tomlinson, I; Burwinkel, B; Marme, F; Guénel, P; Truong, T; Bojesen, SE; Nordestgaard, BG; González-Neira, A; Benitez, J; Neuhausen, SL; Brenner, H; Dieffenbach, AK; Meindl, A; Schmutzler, RK; Brauch, H; Nevanlinna, H; Khan, S; Matsuo, K; Ito, H; Dörk, T; Bogdanova, NV; Lindblom, A; Margolin, S; Mannermaa, A; Kosma, VM; Wu, AH; Van Den Berg, D; Lambrechts, D; Wildiers, H; Chang-Claude, J; Rudolph, A; Radice, P; Peterlongo, P; Couch, FJ; Olson, JE; Giles, GG; Milne, RL; Haiman, CA; Henderson, BE; Dumont, M; Teo, SH; Wong, TY; Kristensen, V; Zheng, W; Long, J; Winqvist, R; Pylkäs, K; Andrulis, IL; Knight, JA; Devilee, P; Seynaeve, C; García-Closas, M; Figueroa, J; Klevebring, D; Czene, K; Hooning, MJ; van den Ouweland, AM; Darabi, H; Shu, XO; Gao, YT; Cox, A; Blot, W; Signorello, LB; Shah, M; Kang, D; Choi, JY; Hartman, M; Miao, H; Hamann, U; Jakubowska, A; Lubinski, J; Sangrajrang, S; McKay, J; Toland, AE; Yannoukakos, D; Shen, CY; Wu, PE; Swerdlow, A; Orr, N; Simard, J; Pharoah, PD; Dunning, AM; Chenevix-Trench, G; Hall, P; Bandera, E; Amos, C; Ambrosone, C; Easton, DF; Cole, MD (2016-07-11)
      Breast cancer is the most diagnosed malignancy and the second leading cause of cancer mortality in females. Previous association studies have identified variants on 2q35 associated with the risk of breast cancer. To identify ...